The effect of chlorpromazine on plasma renin activity and aldosterone in man

The Journal of Clinical Endocrinology and Metabolism
D Robertson, A M Michelakis

Abstract

The response of plasma renin activity (PRA) and aldosterone to the intravenous administration of chlorpromazine was determined in schizophrenic patients while they were supine and on a normal sodium diet. In all subjects PRA and aldosterone increased during chlorpromazine administration with little or no change in blood pressure. The maximum PRA and aldosterone levels occurred 60 min after the higher dose of chlorpromazine. These data suggest that chlorpromazine affects the renin-angiotensin-aldosterone system and it may interfere with the evaluation of this system in patients receiving this drug.

Citations

Oct 1, 1992·Psychoneuroendocrinology·M D WarnerC A Peabody
Dec 1, 1981·Circulation Research·D J CampbellJ W Funder
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Adib EssaliJohn Rathbone

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