The effect of chronic administration of a synthetic LH-RH analogue intranasally in cryptorchid boys

International Journal of Andrology
J FrickG Bernroider

Abstract

Eighteen boys with either unilateral or bilateral cryptorchidism were treated with a synthetic LH-RH analogue ("D-Leu 6, Des-Gly-10 LH-RH ethylamide") intranasally. The peptide was dissolved in aqueous solution (25 micrograms in 0,2 ml) and administered in the form of nasal drops. The patients were divided in two groups: in group A, 50 micrograms of the synthetic LH-RH analogue were administered intranasally every 48 h for 36 days; in group B same dose was given every 24 h. Additionally, in 4 cases a LH-RH test prior the trial was performed with the same peptide. The nasal administration resulted in a fivefold increase of LH and of FSH plasma concentration in 30 min and in 60 min, respectively. The endocrine profiles for T, LH and FSH were studied in each group over the treatment period and in group B (same dose was given every 24 h) a significant decrease of the LH and FSH plasma levels could be found. The clinical effect of treatment was same in the both groups. In the whole material 44% had either unilateral or bilateral descent of the testis after the therapy.

References

Sep 1, 1975·The Journal of Clinical Endocrinology and Metabolism·G R Van Loon, G M Brown
Nov 1, 1973·The Journal of Clinical Endocrinology and Metabolism·D R LondonJ M Stephenson
Sep 1, 1973·The Journal of Clinical Endocrinology and Metabolism·D Gonzalez-BarcenaA V Schally
Apr 1, 1973·Endocrinology·A BartkeB V Caldwell
Feb 1, 1970·The Journal of Clinical Endocrinology and Metabolism·P G CrosignaniD R Mishell

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Citations

Jan 1, 1987·European Journal of Pediatrics·J WaldschmidtA Priefer
Jan 1, 1993·European Journal of Pediatrics·J Frick
Jun 1, 1983·Clinical Endocrinology·J Sandow
May 1, 1986·Clinical Endocrinology·J M WitJ L Van den Brande
Apr 28, 2007·Acta Paediatrica·Arni V ThorssonMartin Ritzén

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