PMID: 3762308Oct 6, 1986Paper

The effect of chronic alcohol inhalation on blood pressure and the pressor response to noradrenaline and the thromboxane-mimic U46619

Life Sciences
J W KaranianN Salem

Abstract

Rats were exposed to alcohol vapor for 6 days and the mean blood ethanol concentration (BEC) was obtained for each subject. Blood pressure and its reactivity to noradrenaline and a thromboxane-mimic U46619 were directly measured on day 6 via a catheter implanted in the tail artery of normal and ethanol-treated animals. The mean BEC for each subject correlated with mean arterial blood pressure (MAP); an increase in BEC was associated with a decrease in MAP (p less than 0.02). The mean MAP of subjects with BEC less than 168 mg% was 8% higher than normal (not significant), whereas, the mean MAP of subjects with BEC greater than 182 mg% decreased 27 +/- 4% (p less than 0.01). Conversely, the pressor response to U46619 was markedly enhanced (p less than 0.005) in rats with mean BEC greater than 182 mg% at all doses investigated (12.5-3200 ng per rat). Increases in the pressor response to noradrenaline in ethanol-treated rats were significant only when maximally stimulated by 400 and 800 ng doses (p less than 0.03). A 3-fold increase in sensitivity for U46619 was seen in subjects with high mean BEC, however, sensitivity for noradrenaline did not significantly change. Vasoreactivity was not effected in rats with mean BEC less than 168...Continue Reading

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Citations

Jan 1, 1992·Archives of Toxicology·P HoffmannG Zbinden
Jan 1, 1988·Pharmacology & Therapeutics·L A Pohorecky, J Brick
Aug 28, 2003·Clinical and Experimental Hypertension : CHE·Mahmoud M El-MasS Jamal Mustafa
Feb 15, 2011·Brain Research Reviews·Patricia S BrocardoBrian R Christie
Oct 6, 2005·Alcoholism, Clinical and Experimental Research·Steven C Brunell, Linda P Spear

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