PMID: 8944409Nov 1, 1996Paper

The effect of chronic fluvoxamine on hormonal and psychological responses to buspirone in normal volunteers

Psychopharmacology
I M AndersonH E Miller

Abstract

We studied the effect of 3 weeks treatment with the selective serotonin reuptake inhibitor (SSRI), fluvoxamine, on hormonal and psychological responses to buspirone, a 5-HT1A receptor partial agonist which also binds to dopamine receptors, in normal male volunteers. Eleven subjects received buspirone, 30 mg, and placebo before, and in week 3 of fluvoxamine treatment (mean dose 127 mg/day). Placebo and buspirone were given in a balanced order, double-blind. Buspirone significantly elevated plasma prolactin (PRL) and growth hormone (GH) concentrations but had no significant effect on cortisol (CORT) or temperature. Significant psychological effects of lightheadedness, tiredness and difficulty thinking occurred. Fluvoxamine treatment resulted in a nearly 3-fold increase in plasma buspirone with a similar enhancement of the PRL response. In contrast the GH and psychological responses were blunted. The increased buspirone concentrations are likely to be due to inhibition of first pass liver metabolism by fluvoxamine acting on the cytochrome P-450 system. The PRL response is probably mediated by antagonism of pituitary dopamine-D2 receptors and its enhancement by fluvoxamine treatment may be a pharmacokinetic effect. The blunting of ...Continue Reading

Citations

Sep 30, 1999·Life Sciences·D K Raap, L D Van de Kar
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eliyahu DremencovMichael E Newman
Jun 29, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·E DremencovM E Newman
Aug 30, 2000·Nuclear Medicine and Biology·P J Cowen
Aug 16, 2011·Psychopharmacology·Rafael G Dos SantosJordi Riba
Apr 11, 2001·Journal of Clinical Child Psychology·M A Grados, M A Riddle
Mar 23, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hiroyuki NishikawaTsukasa Koyama
Jul 6, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Etsuko KasuyaMadoka Sutoh
Aug 7, 1998·Journal of Psychopharmacology·T M Andrews, I M Anderson
Feb 28, 2003·Psychopharmacology·C J HarmerP J Cowen
Feb 18, 2003·Psychopharmacology·R H McAllister-Williams, A E Massey
Nov 10, 2009·Scandinavian Journal of Medicine & Science in Sports·S LockeP O'Rourke

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