The effect of chronic nitric oxide synthesis inhibition on blood pressure and angiotensin II responsiveness in the pregnant rat

American Journal of Obstetrics and Gynecology
S L LubarskyBaha M Sibai

Abstract

Our purpose was to determine whether blockade of inducible or endothelial nitric oxide synthesis prevents maternal vasodilation and blunting of angiotensin II responsiveness in the pregnant rat. Pregnant and nonpregnant rats were given (1) drinking water alone (untreated), (2) drinking water containing the inducible nitric oxide synthase inhibitor aminoguanidine (0.5 gm/L), or (3) drinking water containing the nonselective nitric oxide synthase inhibitor N omega-nitro-L-arginine methyl ester (0.5 gm/L) from postmating days 5 to 21. On days 7, 14, and 20, 24-hour urinary nitrate-nitrite excretion, urine protein concentration, hematocrit, mean arterial blood pressure, and pressor responses to angiotensin II (12.5 to 200 ng/kg) were measured. On day 21 litter size, fetal weight, and fetal mortality were determined. Urinary nitrate-nitrite excretion was increased, and hematocrit and blood pressure were decreased by day 20 of pregnancy. Angiotensin II pressor responses were decreased on days 14 and 20 of pregnancy. Aminoguanidine slightly decreased nitrate-nitrite excretion in pregnant, but not nonpregnant rats, and abolished the late pregnancy increase. Aminoguanidine did not affect hematocrit, blood pressure, or angiotensin II res...Continue Reading

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Citations

Feb 11, 2009·Journal of Vascular Research·George OsolMaurizio Mandala
Aug 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Sarah A HaleGeorge Osol
Nov 14, 2013·PloS One·Anne Marijn van der GraafMarijke M Faas
May 5, 1999·Fundamental & Clinical Pharmacology·A M DieyeA Gairard
Sep 5, 2003·Archives of Gynecology and Obstetrics·Maite Carbajo RuedaLina Fernández Celadilla
Mar 26, 2005·Archives of Gynecology and Obstetrics·Lina Fernández CeladillaManuel Muñoz Rodríguez
Feb 13, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P JavadianA R Dehpour
Mar 23, 2001·American Journal of Obstetrics and Gynecology·I A BuhimschiR E Garfield
Dec 1, 2000·Human Reproduction·J J Dalle LuccaN L Alsip
Jul 27, 2006·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jessica J Vanderlelie, Anthony V Perkins
Feb 9, 2008·Hypertension·Marilyn J CipollaJulie A Godfrey
Oct 13, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Cláudio Márcio Yudi IkinoNewton Macuco Capella
Dec 25, 2004·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Lina Fernández CeladillaManuel Muñoz Rodríguez
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Apr 2, 1999·Seminars in Perinatology·E PodjarnyG Losonczy

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