The effect of chronic vitamin deficiency and long term very low dose exposure to 6 pesticides mixture on neurological outcomes - A real-life risk simulation approach

Toxicology Letters
Aristidis M TsatsakisVictor A Tutelyan

Abstract

We investigate the long-term effect of very-low dose exposure to a mixture of six pesticides associated with hydrophilic vitamin deficiency on the neurobehavioral outcomes of rats. Two hundred Wistar rats were divided into four groups, two control groups, a vitamin sufficient control group and a vitamin deficiency control group and 2 test groups, a vitamin sufficient test group, and a vitamin deficiency group. The test groups were exposed for 9 months to a mixture of diquat, imazamox, imazethapyr, tepraloxydin, bentazone and acifluorfen in doses of 0.01xNOAEL (mg/kg bw/day). After 9 months of exposure, the behavior changes were evaluated by open field test and elevated plus maze test and the memory was assessed by passive avoidance test. Chronic vitamin deficiency decreased locomotor and special orientation activity and increased anxiety-like behavior in rats. Exposure to very low doses of a mixture of 6 pesticides caused central nervous effects, manifested as decreased locomotor activity, and increased anxiety levels. Vitamin deficiency and low dose chronic pesticides mixture exposure thus affected the central nervous system, especially long-term memory.

Citations

Apr 23, 2020·International Journal of Molecular Medicine·Anatoly V SkalnyAlexey A Tinkov
Jul 31, 2020·Dose-response : a Publication of International Hormesis Society·Edward J CalabreseVittorio Calabrese
Jun 14, 2020·International Journal of Environmental Research and Public Health·Denisa MarginăAristidis Tsatsakis
Aug 18, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ronald N KostoffAristidis Tsatsakis
Dec 10, 2020·Journal of Toxicology·Nadezhda V TyshkoValentin M Zhminchenko
Apr 26, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ronald N KostoffAristidis Tsatsakis
Nov 6, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Valentin NăstăsescuManuela Ghica
Sep 22, 2020·Toxicology Reports·Nataliya A IlyushinaAristidis Tsatsakis
May 20, 2020·Toxicology Reports·Efthimios DardiotisGeorgios M Hadjigeorgiou
Mar 8, 2020·Toxicology Letters·Athina-Maria AloizouEfthimios Dardiotis
Jul 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mahmoud HashemzaeiRamin Rezaee
Apr 10, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Aristidis TsatsakisAnca Oana Docea
Jul 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Denisa MarginăAristidis Michael Tsatsakis

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