PMID: 423042Mar 1, 1979

The effect of cimetidine on maldigestion in cystic fibrosis

The Journal of Pediatrics
K L CoxR R Dooley

Abstract

Ten patients (6 to 27 years of age) who had severe pancreatic exocrine insufficiency due to cystic fibrosis were studied to determine whether cimetidine would improve dietary fat and nitrogen absorption. When a constant diet was consumed and oral pancreatic enzymes were administered, the addition of cimetidine (150 or 200 mg taken orally one-half hour before meals) signficantly reduced fecal fat excretion from 25.3 +/- 2.9 to 17.3 +/- 2.1 gm/24 hours and fecal nitrogen excretion from 4.5 +/- 0.6 to 3.4 +/- 0.5 gm/24 hours (P less than 0.05). Lower doses of cimetidine resulted in less significant reductions of steatorrhea and azotorrhea. Cimetidine may be a useful adjunct to oral pancreatic enzyme therapy in patients with cystic fibrosis who continue to have steatorrhea and azotorrhea with enzyme therapy alone.

References

Feb 1, 1978·The Journal of Pediatrics·I AntonowiczH Shwachman
Feb 1, 1976·The Journal of Pediatrics·C L MorinA Bonin
Aug 1, 1967·Gut·H S Wiggins

Citations

May 1, 1985·European Journal of Pediatrics·A SomogyiR Gugler
Jan 1, 1988·European Journal of Clinical Pharmacology·J PrandotaJ T Wilson
May 1, 1987·Digestive Diseases and Sciences·C A YoungbergJ B Dressman
Jun 1, 1982·Digestive Diseases and Sciences·E P DiMagno
Jun 1, 1982·Digestive Diseases and Sciences·D Y Graham
Oct 1, 1987·Digestive Diseases and Sciences·R D HoffmanG K Powell
Jan 1, 1991·Nutrition Research Reviews·R ShepherdT L Holt
Sep 1, 1981·Australian Paediatric Journal·E A Mitchell, R B Elliott
May 18, 1999·Archives of Disease in Childhood·C J TaylorN Read
Oct 18, 1986·British Medical Journal·C B Lamers, J B Jansen
Nov 1, 1987·Gut·P L Zentler-Munro
Nov 24, 1998·Journal of Clinical Pharmacology·W A MaishG L Kearns
Jan 1, 1981·Acta paediatrica Scandinavica·F de BiévilleK F Kerrebijn
Jan 1, 1985·Acta paediatrica Scandinavica·D M ChalmersM S Losowsky
Jan 1, 1985·Acta Paediatrica Scandinavica. Supplement·M SinaasappelH J Neijens
Oct 18, 1986·British Medical Journal·N H Kitching
Nov 17, 2005·Pediatric Pulmonology·James M LittlewoodSteven P Conway
Aug 11, 2000·Paediatric Drugs·J M Littlewood, S P Wolfe
Dec 1, 1987·Alimentary Pharmacology & Therapeutics·P L Zentler-Munro, T C Northfield
Feb 1, 1983·Drug Intelligence & Clinical Pharmacy·E M Sorkin, D L Darvey
Aug 1, 1981·British Journal of Clinical Pharmacology·R BradbearR K Roberts
Aug 26, 1998·Journal of the Royal Society of Medicine·P DurieL Ellis
Jan 1, 1982·Scandinavian Journal of Gastroenterology·I L SalomA Doscherholmen

Related Concepts

Teens
Celiac Disease
Tagamet
Pulmonary Cystic Fibrosis
Polychemotherapy
Guanidines
Malabsorption Syndrome
Pancreatic Extracts
Panzytrat

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