Abstract
The present systematic review and meta-analysis was performed to evaluate the effect of cinnamon supplementation on blood lipid profiles in patients with type 2 diabetes. A systematic search (with no language restrictions) was performed in PubMed, Embase, Scopus, Web of Science, and Cochrane Library to identify relevant clinical trials up to 8th March 2020. Weighted mean differences (WMDs) and 95 % confidence intervals (CI) were pooled based on the random-effects model. Heterogeneity, publication bias, and sensitivity analyses were performed based on standard methods. Sixteen studies, involving 1025 participants, were included in the meta-analysis. This study found a significant decrease in triglycerides (TG) (WMD: -26.27 mg/dl, 95 % CI: [-38.93, -13.61], P < 0.001), total cholesterol (TC) (WMD: -13.93 mg/dl, 95 % CI: [-25.64, -2.22], P = 0.020), and low-density lipoprotein cholesterol (LDL-C) levels (WMD: -6.13 mg/dl, 95 % CI: [-10.72, -1.53], P = 0.009), while no change was observed on high-density lipoprotein cholesterol (HDL) concentration (WMD: 0.64 mg/dl, 95 % CI: [-0.18, 1.46], P = 0.128), in patients with type 2 diabetes. The reduction in TG, TC, and LDL-C was greater in; Eastern compared to Western countries, and studi...Continue Reading
References
Aug 5, 1997·Circulation·C GerdesO Faergeman
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Nov 5, 1999·Diabetes Care·D Haire-JoshuT L Tibbs
Sep 15, 2001·The New England Journal of Medicine·F B HuW C Willett
May 8, 2003·Lipids·Frank B Hu
Oct 31, 2003·Journal of Medicinal Food·Jeong-Sun LeeMyung-Sook Choi
Nov 25, 2003·Diabetes Care·Alam KhanRichard A Anderson
Apr 28, 2004·Diabetes Care·Sarah WildHilary King
Jul 28, 2005·The Journal of Nutrition·Krista A Varady, Peter J H Jones
Dec 13, 2005·American Heart Journal·Ana CenarroUNKNOWN ATOMIX Study Group
Mar 22, 2006·The Journal of Nutrition·Kristof VanschoonbeekLuc J C van Loon
Apr 26, 2006·European Journal of Clinical Investigation·B MangA Hahn
Jun 15, 2007·Diabetes Care·Steve M BlevinsChristopher E Aston
Jul 13, 2007·Clinical Science·Amal MuthumalaSteve E Humphries
Sep 25, 2007·Journal of Lipid Research·Yin RuixingQin Shuming
Feb 19, 2008·The Journal of Pharmacology and Experimental Therapeutics·Yuji TanakaCurtis D Klaassen
May 27, 2008·Journal of the International Society of Sports Nutrition·Tim N ZiegenfussRichard A Anderson
Nov 11, 2008·The Journal of Nutritional Biochemistry·Bolin QinRichard A Anderson
Dec 20, 2008·PPAR Research·Xiaoyan ShengYing Qin Zang
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Oct 13, 2009·Diabetologia·X WangH Snieder
Feb 17, 2010·Metabolic Syndrome and Related Disorders·Peter SchwandtGerda-Maria Haas
Mar 3, 2010·Archives of Pharmacal Research·Sung Hee Kim, Se Young Choung
Jun 3, 2010·Archives of Biochemistry and Biophysics·K CouturierA M Roussel
Sep 22, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·R AkilenN Robinson
Oct 7, 2010·Critical Reviews in Food Science and Nutrition·Joerg GruenwaldNicole Armbruester
Oct 14, 2010·Current Medicinal Chemistry·S-M HeS-F Zhou
Dec 28, 2010·Journal of Clinical Epidemiology·Gordon H GuyattAndre Knottnerus
Jan 5, 2011·Journal of Clinical Epidemiology·Gordon GuyattHolger J Schünemann
Jul 9, 2011·PLoS Genetics·Logan DumitrescuDana C Crawford
Aug 25, 2011·Journal of Medicinal Food·Julio WainsteinMona Boaz
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Jul 4, 2012·Nutrition Research·Ting LuYan Chen
Sep 11, 2013·Annals of Family Medicine·Robert W AllenOlivia J Phung
Jan 1, 2012·Journal of Traditional and Complementary Medicine·Yan ShenTaiichiro Seki
Jul 16, 2015·The Review of Diabetic Studies : RDS·Paria AzimiBehnoud Abbasi
Sep 25, 2015·Journal of Intercultural Ethnopharmacology·Mostafa Abbas Shalaby, Hamed Yahya Saifan
Oct 14, 2016·Journal of Atherosclerosis and Thrombosis·Ryo NaitoHiroyuki Daida
Apr 12, 2017·Oxidative Medicine and Cellular Longevity·Zeynep TuzcuKazim Sahin
May 30, 2017·Gene·Ting-Ting ZengHong Jiang
Sep 10, 2017·Journal of Clinical Lipidology·Serban M MaiereanUNKNOWN Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
Apr 2, 2018·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Roghayeh ZareMojtaba Heydari
Apr 18, 2018·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mahdie HajimonfarednejadMojtaba Heydari
Sep 8, 2018·Biological Trace Element Research·Luísa L GonçalvesJosé A Brito
Sep 17, 2018·Complementary Therapies in Medicine·Maryam Akbari-FakhrabadiFarzad Shidfar
Sep 22, 2018·Toxicology and Applied Pharmacology·In-Geun Ryoo, Mi-Kyoung Kwak
Jul 9, 2015·Diabetology International·Chintana SengsukSurapon Tangvarasittichai
Apr 3, 2019·Complementary Therapies in Medicine·Nazli NamaziBagher Larijani
Aug 20, 2019·Diabetes Research and Clinical Practice·Serawit DeynoPatrick Engeu Ogwang
Feb 8, 2020·Diabetes & Metabolic Syndrome·Navid JamaliAli Samareh