The effect of clarithromycin on inflammatory markers in chronic obstructive pulmonary disease: preliminary data

The Annals of Pharmacotherapy
Ilknur BasyigitAhmet Ilgazli

Abstract

Clarithromycin is an antimicrobial agent that can be used for treatment of chronic obstructive pulmonary disease (COPD) exacerbations with bronchodilator therapy. However, it has also been shown that clarithromycin has antiinflammatory effects by the inhibition of cytokine production. To evaluate the antiinflammatory effect of clarithromycin on serum and sputum interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), and leukotriene B4 levels in patients with COPD. Thirty men with mild to moderate COPD were enrolled in this prospective, single-center, double-blind, placebo-controlled study. None of the patients was receiving systemic or inhaled corticosteroids during the study. Subjects received either clarithromycin or placebo for 14 days. Before and after this treatment period, spirometric tests and arterial blood gas analysis were performed, blood was drawn for measurement of serum inflammatory markers, and sputum was induced. There were no statistically significant differences in baseline clinical or laboratory parameters between the groups. After the treatment, the induced sputum total cell counts, and IL-8 and TNF-alpha levels decreased significantly in the clarithromycin group compared with pretreatment levels (mea...Continue Reading

References

Jan 1, 1990·The American Review of Respiratory Disease·S K GoswamiZ Marom
Aug 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T PopovF E Hargreave
Aug 1, 1993·Journal of Chemotherapy·F ScaglioneF Fraschini
Jun 1, 1996·Antimicrobial Agents and Chemotherapy·K MorikawaS Morikawa
Dec 1, 1996·The Journal of Allergy and Clinical Immunology·T AdachiS Makino
May 14, 1998·The Journal of Antimicrobial Chemotherapy·M T Labro
Nov 21, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E BacciP L Paggiaro
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Z DiamantP J Sterk
Mar 8, 2000·Respiration; International Review of Thoracic Diseases·F YildizO Ozkarakaş

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Citations

Jul 11, 2012·Mediators of Inflammation·Helen C SteelCharles Feldman
Nov 23, 2007·Respiration; International Review of Thoracic Diseases·Zhiyi HePixin Ran
Oct 24, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Iskander Al-GithmiAnthony Yim
Nov 23, 2011·European Journal of Clinical Pharmacology·P ZarogoulidisK Zarogoulidis
Sep 9, 2005·American Journal of Respiratory and Critical Care Medicine·Trevor J Williams, Geert M Verleden
Jun 3, 2006·American Journal of Respiratory and Critical Care Medicine·Geert M VerledenDirk E Van Raemdonck
Mar 25, 2011·Immunopharmacology and Immunotoxicology·Xinxin CiXuming Deng
Nov 6, 2010·Chest·Adam L Friedlander, Richard K Albert
Jul 30, 2011·The Urologic Clinics of North America·Daniel A Shoskes, J Curtis Nickel
Feb 15, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nikola MarjanovićVesna Eraković Haber
Feb 6, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Raksha JainMichael J Walter
Dec 8, 2009·Archivos de bronconeumología·Daniel Sevilla-SánchezNéstor Soler-Porcar
Dec 23, 2009·Pulmonary Pharmacology & Therapeutics·Francesco BlasiEnrico Guffanti
Jun 30, 2009·European Journal of Pharmacology·Boska HrvacićVesna Eraković Haber
Oct 31, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Desmond M MurphyChris Ward
Oct 16, 2007·International Journal of Antimicrobial Agents·Evangelos J Giamarellos-Bourboulis
Jan 26, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K M Beeh, J Beier
Mar 1, 2011·Clinical Transplantation·Gundeep S DhillonDavid Weill
Jun 10, 2010·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Michael B RothbergPeter K Lindenauer
Feb 9, 2005·Diagnostic Microbiology and Infectious Disease·Laurel C PreheimMartha J Gentry-Nielsen
Dec 3, 2010·Journal of Chemotherapy·B Butorac-PetanjekS Popovic-Grle
Mar 5, 2014·European Journal of Medical Research·Alling ZhuXin Yao
Jun 15, 2007·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Salman Siddiqui, Christopher E Brightling
Nov 1, 2006·Revue de pneumologie clinique·M LangelotP Germaud
Sep 6, 2011·Therapeutic Advances in Respiratory Disease·Mathieu CoemanGuy Brusselle
Jan 11, 2019·International Forum of Allergy & Rhinology·Zhenxiao Huang, Bing Zhou
Mar 1, 2005·Current Opinion in Infectious Diseases·Michael J Parnham
Jan 31, 2006·Expert Review of Anti-infective Therapy·Fernando J MartinezJeffrey Curtis
Oct 20, 2007·American Journal of Respiratory and Critical Care Medicine·Jodie L SimpsonPeter G Gibson

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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