PMID: 108714Mar 14, 1979

The effect of clonidine withdrawal on total 3-methoxy-4-hydroxyphenylglycol in the rat brain

S W TangH C Stancer


The effect of clonidine withdrawal on the brain norepinephrine system was studied in the rat. Clonidine suppresses brain total 3-methoxy-4-hydroxyphenylglycol (MHPG) significantly and no tolerance to this effect was observed up to 21 days. Cessation of clonidine treatment resulted in an elevation in the level of brain total MHPG. The suitability of the clonidine withdrawal syndrome as a model of bipolar depression is discussed.


Aug 15, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·T H Svensson, U Strömbom
Dec 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·S TakahashiH C Stancer
Nov 1, 1965·The American Journal of Psychiatry·J J Schildkraut
Aug 1, 1968·Archives of General Psychiatry·J W MaasH Dekirmenjian


Jan 1, 1986·Psychopharmacology·M P Parale, S K Kulkarni
Jan 1, 1984·Psychopharmacology·P R MartinI J Kopin
Jan 1, 1982·General Pharmacology·M Parker, J Atkinson
Jan 1, 1981·Annals of the New York Academy of Sciences·M S Gold, A C Pottash
Jan 1, 1991·Neuroscience and Behavioral Physiology·M Kh LevitmanL Kh Eidus

Related Concepts

Methoxyhydroxyphenylglycol, (+)-Isomer
Withdrawal Symptoms
Rats, Laboratory

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