The effect of clove and benzocaine versus placebo as topical anesthetics

Journal of Dentistry
Athbi AlqareerLars Andersson

Abstract

The purpose of this study was to examine whether the natural herb clove can replace benzocaine as a topical anesthetic. Topical agents were applied to the maxillary canine buccal mucosa of 73 adult volunteers. Four substances were tested in the study: (1) homemade clove gel, (2) benzocaine 20% gel, (3) placebo that resembles clove and (4) a placebo that resembled benzocaine. After 5 min of material application in a randomized, subject-blinded manner, each participant received two needle sticks. Pain response was registered using a 100 mm visual analogue pain scale. Both clove and benzocaine gels had significantly lower mean pain scores than placebos (p=0.005). No significant difference was observed between clove and benzocaine regarding pain scores. Clove gel might possess a potential to replace benzocaine as a topical agent before needle insertion.

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Citations

Aug 10, 2007·Current Pain and Headache Reports·Barrie CassilethJyothirmai Gubili
Dec 19, 2012·Journal of Liposome Research·Michelle Franz-MontanEneida de Paula
Nov 13, 2012·Expert Opinion on Drug Delivery·Eneida de PaulaFrancisco C Groppo
Nov 30, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Michelle Franz-MontanMaria C Volpato
Jun 15, 2010·Journal of Clinical Anesthesia·Michelle Franz-MontanFrancisco C Groppo
Sep 14, 2007·Journal of Clinical Periodontology·Jill L StoltenbergBryan S Michalowicz
Sep 19, 2006·Explore : the Journal of Science and Healing·Tieraona Low Dog
Apr 7, 2017·Journal of Cosmetic Dermatology·Ibrahim M IbrahimMahmoud H Mohey-Eddin
Oct 28, 2016·Chinese Journal of Integrative Medicine·Keyal UmaBhatta Anil Kumar
Mar 20, 2020·Anesthesia Progress·Lydia ParkThomas Tanbonliong
Jul 24, 2020·Animals : an Open Access Journal From MDPI·Sandra FrahmSusanne Waiblinger
Sep 17, 2020·Journal of Dental Anesthesia and Pain Medicine·Krishnan PadmineeGnanabagyan J Trophimus

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