The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers

Molecular Nutrition & Food Research
Walter BrandIvonne M C M Rietjens

Abstract

Metabolism by phase II enzymes and transport from intestinal cells back into the lumen by ATP binding cassette (ABC) transporters limits the bioavailability of the flavanone hesperetin, the aglycone of hesperidin. This study investigates to what extent other flavonoids modulate the metabolism and transport of hesperetin by characterizing the effect of co-administrating a series of flavonoids using Caco-2 cell monolayers in a two-compartment transwell system. Flavonoids may interfere with hesperetin metabolism and can also inhibit the apically located ABC transporter breast cancer resistance protein (ABCG2) which was previously shown to be responsible for the apical transport of hesperetin metabolites. Co-exposure of Caco-2 cell monolayers to hesperetin with specific flavonoids reduced the ratio of apical efflux to basolateral transport of hesperetin metabolites, and in some cases, also reduced the amount of hesperetin metabolites detected extracellularly. As intracellular accumulation of hesperetin metabolites did not account for this decrease, inhibition of metabolism of hesperetin is likely the underlying mechanism for the reduced metabolite formation and excretion. In spite of the reduction in metabolism the amount of hesper...Continue Reading

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Citations

Jun 19, 2013·Critical Reviews in Food Science and Nutrition·Jianbo XiaoXiaoqing Chen
Feb 9, 2013·Critical Reviews in Food Science and Nutrition·Jianbo XiaoXiaoqing Chen
May 16, 2014·Nutrition Reviews·Torsten Bohn
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Jan 13, 2011·Molecular Nutrition & Food Research·Jianbo XiaoKoichiro Yamamoto
Mar 29, 2014·Molecular Nutrition & Food Research·Mohammed A IslamIvonne M C M Rietjens
May 11, 2011·Nanotoxicology·Jianbo XiaoXiaoqing Chen
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Aug 12, 2014·Critical Reviews in Food Science and Nutrition·Jianbo XiaoXiaoqing Chen
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Dec 12, 2012·Food & Function·Pedro L FaléMaria L M Serralheiro
Mar 18, 2021·European Journal of Pharmacology·Simona SaponaraMassimo Valoti

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