The Effect of Co-Administration of Death Camas (Zigadenus spp.) and Low Larkspur (Delphinium spp.) in Cattle

Toxins
Kevin D WelchDaniel Cook

Abstract

In many rangeland settings, there is more than one potential poisonous plant. Two poisonous plants that are often found growing simultaneously in the same location in North American rangelands are death camas (Zigadenus spp.) and low larkspur (Delphinium spp.). The objective of this study was to determine if co-administration of death camas would exacerbate the toxicity of low larkspur in cattle. Cattle dosed with 2.0 g of death camas/kg BW showed slight frothing and lethargy, whereas cattle dosed with both death camas and low larkspur showed increased clinical signs of poisoning. Although qualitative differences in clinical signs of intoxication in cattle co-treated with death camas and low larkspur were observed, there were not any significant quantitative differences in heart rate or exercise-induced muscle fatigue. Co-treatment with death camas and low larkspur did not affect the serum zygacine kinetics, however, there was a difference in the larkspur alkaloid kinetics in the co-exposure group. Overall, the results from this study suggest that co-exposure to death camas and low larkspur is not significantly more toxic to cattle than exposure to the plants individually. The results from this study increase our knowledge and ...Continue Reading

References

Oct 1, 1988·Poultry Science·W E HuffG E Rottinghaus
Feb 24, 2010·Computer Methods and Programs in Biomedicine·Yong ZhangShaofei Xie
Sep 24, 2013·Toxicon : Official Journal of the International Society on Toxinology·K D WelchD Cook
Oct 22, 2013·Toxicon : Official Journal of the International Society on Toxinology·T Zane DavisJames A Pfister

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Citations

Feb 6, 2017·Toxicon : Official Journal of the International Society on Toxinology·K D WelchJ A Pfister
Jul 17, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·J WątłyM Rowińska-Żyrek

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