The effect of colchicine on the peritoneal membrane

Renal Failure
Hayriye SayarliogluHamza Bozkurt

Abstract

Peritoneal dialysis (PD) is a treatment modality for patients with renal failure. Peritoneal fibrosis is one of the most serious complications after long-term continuous ambulatory peritoneal dialysis (CAPD). Histological studies in both humans and animals show that chronic peritoneal dialysis results in fibrosis of the peritoneal membrane. In our study, we investigated the effect of colchicine on peritoneal alterations induced by hypertonic PD solution in rats. Sprague-Dawley rats intraperitoneally received saline (control group) once daily, for 28 days, or 3.86% glucose (PDF group), or 3.86% glucose plus colchicine (colchicine group). Animals from each group were sacrificed after 28 days with anesthetized ketamine (60 mg/kg BW). For the PD fluid assessment, 1 h before the sacrifice of animals, 10 mL PD fluid of 2.27% glucose was given, and this fluid was obtained after the sacrifice. The levels of transforming endothelial growth factor beta (TGF-beta), tumor necrosis factor alpha (TNF-alpha) and albumin were investigated both in the peritoneal dialysate and blood, and the levels of malondialdehyde (MDA) were investigated only in peritoneal dialysate. The peritoneal membrane was evaluated histologically by light microscopy. Wh...Continue Reading

References

Nov 1, 1975·Arthritis and Rheumatism·S E Malawista
Jun 30, 1988·The New England Journal of Medicine·D KershenobichM Rojkind
Apr 17, 1986·The New England Journal of Medicine·D ZemerJ Gafni
Dec 4, 1986·The New England Journal of Medicine·M M KaplanK A Eagen
Nov 1, 1971·Arthritis and Rheumatism·E D Harris, S M Krane
Jan 1, 1970·Experimental Cell Research·P H Fitzgerald, L A Brehaut
Jan 1, 1993·Chest·S G PetersR A DeRemee
May 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R M FagugliU Buoncristiani
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Peter J MargettsJack Gauldie
Feb 5, 2003·Gynecologic and Obstetric Investigation·Alfonsa PizzoSilvano Marsico
Jan 1, 1996·IEEE Transactions on Neural Networks·S Thirumalai, N Ahuja

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Citations

Aug 26, 2014·Clinical Therapeutics·Nicola DalbethHenry R Wolfe
Nov 27, 2014·International Urology and Nephrology·Ji WangLining Miao

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