The effect of colostrum and colostral antibody SIgA on the physico-chemical properties and phagocytosis of Escherichia coli o86

Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology
K E MagnussonL Edebo

Abstract

A hydrophilic effect of human colostrum and colostral antibody SIgA binding on Escherichia coli o86 has been demonstrated by hydrophobic interaction chromatography on Octyl-Sepharose and partition in a polymer two-phase system containing dextran, poly(ethyleneglycol) and poly(ethyleneglycol)-palmitate. Furthermore, antibody SIgA binding reduced the negative surface charge of the E. coli bacteria. The reaction between centrifuged but not further purified colostrum and bacteria yielded a complex which, compared to bacteria alone, showed decreased negative and increased positive surface charges, the latter being sensitive to pepsin. Binding of SIgA or colostrum to E. coli showed no definite effect on the attachment to and phagocytosis by polymorphonuclear cells in vitro. The effects observed are discussed in relation to the structure of SIgA.

References

Jan 1, 1975·Immunological Communications·L EdeboC Tagesson
May 1, 1976·Quarterly Reviews of Biophysics·D Beale, A Feinstein
Jan 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·A ZipurskyJ Bienenstock
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans

Related Concepts

Bacteriological Techniques
Binding Sites, Antibody
Chromatography
Colostrum
Alkalescens-Dispar Group
Immunofluorescence Assay
IgA2
Colostral IgA
Neutrophil Band Cells
Pepsin 3

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