The effect of combination of recombinant human bone morphogenetic protein-2 and basic fibroblast growth factor or insulin-like growth factor-I on dental implant osseointegration by confocal laser scanning microscopy

Journal of Periodontology
Jing LanXiangrong Cheng

Abstract

The healing period of bone-implant osseointegration usually varies from 3 to 6 months or even longer. Failure may occur during this time. This study aimed to investigate whether osseointegration of dental implants can be enhanced by the combination of growth factors. Sixty-four implants were coated with polylactic acid and divided into four groups. Group I was applied with 1.0 mg recombinant human bone morphogenetic protein-2 (rhBMP-2) and 200 microg recombinant human basic fibroblast growth factor (rhbFGF), group II with 1.0 mg rhBMP-2 and 250 mug recombinant human insulin-like growth factor-I (rhIGF-I), group III with 1.0 mg rhBMP-2, and group IV without growth factors as control. In total, 16 rabbits were used, and two osteotomies were drilled on each side of the femur, in which four different groups were randomly placed. Four weeks after implanting, 20 mg calcein green/kg body weight was administered intravenously, and 8 weeks after implanting, 20 mg alizarin/kg body weight was administered intravenously. Twelve weeks after implanting, the animals were sacrificed. The block of bone with implants was embedded in methylmethacrylate and sectioned, and the percentage of new bone surrounding the implant was analyzed by confocal ...Continue Reading

References

Aug 1, 1989·The Journal of Clinical Investigation·S E LynchH N Antoniades
Aug 1, 1989·Acta Orthopaedica Scandinavica·P Aspenberg, L S Lohmander
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S E LynchH N Antoniades
Dec 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E Canalis, B Gabbitas
Jun 1, 1993·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·W XiangX Yang
Apr 29, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F DebiaisP J Marie
Apr 30, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J M SchmittJ O Hollinger
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T SakouP Ten Dijke
Oct 16, 1999·Clinical Oral Implants Research·K BesshoJ L Ong
Mar 1, 2000·Journal of Periodontology·S J MerawT M Sioussat
Mar 27, 2001·The Journal of Bone and Joint Surgery. American Volume·A H Reddi
Apr 11, 2003·Nature·Stephen M WarrenMichael T Longaker
May 21, 2003·Clinical Oral Implants Research·Victoria Franke StenportShinichiro Oida
Sep 13, 2003·Clinical Oral Implants Research·Ronald E JungFranz E Weber
Feb 28, 2004·Expert Reviews in Molecular Medicine·Jacky Bonaventure, Vincent El Ghouzzi

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Citations

Nov 19, 2009·Annals of Biomedical Engineering·Lei WangChangsheng Liu
Nov 3, 2010·Tissue Engineering. Part B, Reviews·Diederik H R KempenWouter J A Dhert
Oct 16, 2012·Journal of Pharmacy & Bioallied Sciences·Karuppanan P SasikumarJayaprakash S Gadagi
Mar 2, 2016·Journal of Indian Prosthodontic Society·Sherman Salim, Maretaningtias Dwi Ariani
May 25, 2013·Advanced Materials·Tayebeh AmeriChristoph J Brabec
Jan 15, 2010·Clinical Oral Implants Research·Po-Chun ChangWilliam V Giannobile
Mar 18, 2009·Journal of Biomedical Materials Research. Part a·Abdullah C AkmanRahime M Nohutcu
Mar 29, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Cornelia Katharina MuellerStefan Schultze-Mosgau
May 11, 2016·Archives of Oral Biology·Fawad JavedGeorgios E Romanos
Mar 22, 2012·Advanced Drug Delivery Reviews·William J King, Paul H Krebsbach
Sep 27, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H H XuX Y Li
Jan 7, 2014·Journal of Dental Research·A C CarreiraJ M Granjeiro
Mar 26, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hitoshi IgaiHiroyasu Yokomise
Jun 3, 2021·Materials·Saturnino Marco LupiSilvana Rizzo

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