The effect of combined photobiomodulation and curcumin on skin wound healing in type I diabetes in rats

Journal of Photochemistry and Photobiology. B, Biology
Hasan SoleimaniMohammad Bayat

Abstract

The purpose of the present scientific study was to analyze the effects of combined pulsed wave Photobiomodulation (PW PBM) and Curcumin on the microbial flora; in addition, the tensiometrical wounds properties for type one diabetes mellitus (TIDM) in an experimental animal model. TIDM induction was performed in thirty rats. In the entire animals, one full-thickness excision was implemented on their backs. Randomly, the divisions of rats into 5 groups took place. The primary group was considered as the control group and did not receive any treatment. The secondary group (placebo) received sesame oil by gastric gavage. The third group received PWPBM (890 nm, 80 Hz, 0.2 J/cm2). The fourth group received curcumin (40 mg/kg, which was dissolved in sesame oil) by gastric gavage. Eventually, the fifth group received PW PBM + curcumin. Precisely, on day 7, microbiological examinations, and on the 15th day microbiological and tensiometrical examinations were conducted. The data were analyzed by statistical tests. PW PBM, significantly exacerbated tensiometrical properties of the TIDM repairing wound. PW PBM, curcumin, and PWPBM + curcumin significantly decreased colony forming units compared to the control and the placebo groups indeed....Continue Reading

Citations

Sep 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bharath Kumar VelmuruganChing-Feng Weng
Dec 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiangjun LiuShaoqi Tian
May 24, 2019·Journal of Lasers in Medical Sciences·Amin FirouziFatemeh Fadaei Fathabadi
Jan 25, 2021·Lasers in Medical Science·Adenilson de Souza da FonsecaFlavia de Paoli

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