The effect of combined treatment with morphine sulphate and low-dose ketamine in a prehospital setting.

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Patric JohanssonAnders Johansson

Abstract

Pain is a common condition among prehospital patients. The present study is designed to determine whether adding low-dose ketamine as additional analgesia improves the pain/nausea scores and hemodynamic parameters compared to morphine sulphate alone among patients with bone fractures. Prospective, prehospital clinical cohort study. Twenty-seven patients were included with acute pain. Eleven patients received morphine sulphate 0.2 mg/kg (M-group) and 16 patients received morphine sulphate 0.1 mg/kg combined with 0.2 mg/kg ketamine (MK-group). Scores for pain, nausea, sedation (AVPU) and the haemodynamic parameters (systolic blood pressures (BP), heart rate (HR) and peripheral oxygen saturation (SpO2) were recorded at rescue scene before the start of analgesia and subsequently to admission at hospital. Mean treatment time 46 +/- 17 minutes in the M-group and 56 +/- 11 minutes in the MK-group, respectively (ns). Mean doses of morphine sulphate in the M-group were 13.5 +/- 3.2 mg versus 7.0 +/- 1.5 mg in the MK-group. The mean additional doses of ketamine in the MK-group were 27.9 +/- 11.4 mg. There were significantly differences between the M- and the MK-group according to NRS scores for pain (5.4 +/- 1.9 versus 3.1 +/- 1.4) and B...Continue Reading

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Citations

Jul 13, 2013·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Sebastian BergrathJörg Christian Brokmann
Oct 9, 2012·The American Journal of Emergency Medicine·John R Richards, Rachel E Rockford
Feb 9, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Avi A Weinbroum
Sep 14, 2012·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Brooks WalshGregory L Larkin
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Jan 28, 2015·The American Journal of Emergency Medicine·Joshua P MillerVikhyat S Bebarta
May 19, 2018·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·E Stein BronskyDavid Bar-Or
Jul 19, 2018·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Nicholas KarlowEvan S Schwarz
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Sep 4, 2019·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Diana M SobierajWilliam L Baker
Apr 16, 2020·Prehospital and Disaster Medicine·Akhil BansalBrian Burns
Sep 5, 2020·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Emily J RobinsonLawrence H Brown
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Apr 14, 2018·Drugs·Sophia Sheikh, Phyllis Hendry
Feb 9, 2019·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Kristian D FriesgaardLone Nikolajsen
Apr 20, 2019·Pain Research and Treatment·Ayman A MetryFady A Abdelmalek
Dec 13, 2017·Deutsches Ärzteblatt International·David HäskeMichael Bernhard
Feb 3, 2021·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Christopher RuggMathias Ströhle
Jan 19, 2022·Pain and Therapy·Kristian Dahl FriesgaardLeif Rognås

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