The effect of comorbidity on the use of adjuvant chemotherapy and type of regimen for curatively resected stage III colon cancer patients

Cancer Medicine
Mei-Chin HsiehVivien W Chen

Abstract

Postsurgical chemotherapy is guideline-recommended therapy for stage III colon cancer patients. Factors associated with patients not receiving adjuvant chemotherapy were identified in numerous studies; comorbidity was recognized as an important factor besides patient's age. We assessed the association between comorbidity and the use of adjuvant chemotherapy and type of chemotherapy regimen. Stage III colon cancer patients who underwent surgical resection were obtained from ten Centers for Disease Control and Prevention (CDC)-NPCR Specialized Registries which participated in the Comparative Effectiveness Research (CER) project. Comorbidity was classified into no comorbidity recorded, Charlson, non-Charlson comorbidities, number, and severity of Charlson comorbidity. Pearson chi-square test and multivariable logistic regression were employed. Of 3180 resected stage III colon cancer patients, 64% received adjuvant chemotherapy. After adjusting for patient's demographic and tumor characteristics, there were no significant differences in receipt of chemotherapy between Charlson and non-Charlson comorbidity. However, patients who had two or more Charlson comorbidities or had moderate to severe disease were significantly less likely t...Continue Reading

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Citations

Sep 25, 2019·Cancer Medicine·Irene Zarcos-PedrinaciUNKNOWN REDISSEC-CaMISS Group
May 19, 2020·Intestinal research·Carlos Quezada-GutiérrezEvangelina Montes-Villaseñor
May 13, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Antara BanerjeeSusmita Roy
Oct 24, 2019·Current Pharmaceutical Design·Anjali Takke, Pravin Shende
Nov 16, 2018·South Asian Journal of Cancer·Sampada B DessaiSatheesan Balasubramanian
Dec 17, 2018·Biosensors & Bioelectronics·Majid SharifiMojtaba Falahati

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Methods Mentioned

BETA
surgical resection

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