The effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress

Brain and Behavior
Kristel KlausKyla Pennington

Abstract

Previous research has indicated that variation in genes encoding catechol-O-methyltransferase (COMT) and dopamine receptor D2 (DRD2) may influence cognitive function and that this may confer vulnerability to the development of mental health disorders such as schizophrenia. However, increasing evidence suggests environmental factors such as early life stress may interact with genetic variants in affecting these cognitive outcomes. This study investigated the effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress in healthy adults. One hundred and twenty-two healthy adult males (mean age 35.2 years, range 21-63) were enrolled in the study. Cognitive function was assessed using Cambridge Neuropsychological Test Automated Battery and early life stress was assessed using the Childhood Traumatic Events Scale (Pennebaker & Susman, 1988). DRD2 C957T was significantly associated with executive function, with CC homozygotes having significantly reduced performance in spatial working memory and spatial planning. A significant genotype-trauma interaction was found in Rapid Visual Information Processing test, a measure of sustained attention, with CC carriers who had experienced early...Continue Reading

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Citations

Oct 26, 2018·Cognitive, Affective & Behavioral Neuroscience·M R EhlersR M Todd
Aug 21, 2020·Chronobiology International·Rachael A MuckBrieann C Satterfield
Jan 1, 2019·Mental Illness·Shawna Chan, Robert Bota
Apr 9, 2020·International Journal of Molecular Sciences·Alejandra KoenekeJanet Hoenicka
Sep 16, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O Yu Fedorenko, S A Ivanova
Mar 6, 2019·Neuroscience and Biobehavioral Reviews·Kristel KlausKyla Pennington

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Datasets Mentioned

BETA
Z26491

Methods Mentioned

BETA
PCR
Genotyping

Software Mentioned

OTS
Primer3
Power
CANTAB
SPSS

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