PMID: 3190995Oct 1, 1988Paper

The effect of concurrent aspirin upon plasma concentrations of tenoxicam

British Journal of Clinical Pharmacology
R O DayD Wade

Abstract

1. The effect of chronic, high-dose aspirin therapy upon the disposition of a single dose and multiple doses of tenoxicam was examined in normal volunteers. 2. Aspirin caused a 24% drop in the t1/2 (P less than 0.005), a 49% rise in the volume of distribution (P less than 0.0003) and a 98% increase in the clearance (P less than 0.0001) of tenoxicam after a single dose of the tenoxicam. 3. Steady-state concentrations of tenoxicam decreased significantly from 10.4 +/- 1.5 to 4.5 +/- 1.6 micrograms ml-1 in the presence of chronic, high-dose aspirin treatment. 4. Tenoxicam percentage free measured in plasma from a normal volunteer was 0.56 +/- 0.05% over the tenoxicam concentration range 1-20 micrograms ml-1 and rose to 1.24 +/- 0.07% in the presence of aspirin 150 micrograms ml-1. 5. The effect of aspirin upon the disposition of tenoxicam was consistent with a competitive protein binding interaction.

References

Nov 1, 1979·British Journal of Clinical Pharmacology·D M GrennanM Mackinnon
Jul 1, 1976·Arthritis and Rheumatism·R F Willkens, E J Segre
Jan 1, 1987·European Journal of Drug Metabolism and Pharmacokinetics·R J FrancisV Wright
Sep 1, 1987·British Journal of Clinical Pharmacology·R O DayD Wade
Apr 1, 1986·British Journal of Clinical Pharmacology·F M DunaganB Whiting
Nov 1, 1985·British Journal of Rheumatology·H A BirdV Wright
Oct 1, 1985·European Journal of Drug Metabolism and Pharmacokinetics·R J FrancisP A Harris
Oct 1, 1984·British Journal of Clinical Pharmacology·M EsquivelD H Shaw
Jun 1, 1982·Clinical Pharmacology and Therapeutics·R O DayH E Paulus
Jan 1, 1980·British Journal of Clinical Pharmacology·R H RumbleM S Roberts
Jun 1, 1954·The Biochemical Journal·P TRINDER

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Citations

Nov 1, 1992·The Journal of Pharmacy and Pharmacology·L G Lopez-BustamanteD Fos
Feb 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M Del PuppoE Chiesara
Dec 5, 2006·Journal of Pharmaceutical and Biomedical Analysis·Iulia SoraAndrei Medvedovici

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