The effect of conjugated linoleic acid on plasma lipoproteins and tissue fatty acid composition in humans

Lipids
P BenitoV Simon

Abstract

Conjugated linoleic acid (CLA) has been suggested by some animal studies to possess antiatherogenic properties. To determine, in humans, the effect of dietary CLA on blood lipids, lipoproteins, and tissue fatty acid composition, we conducted a 93-d study with 17 healthy female volunteers at the Metabolic Research Unit of the Western Human Nutrition Research Center. Throughout the study, subjects were fed a low-fat diet [30 energy percent (en%) fat, 19 en% protein, and 51 en% carbohydrate] that consisted of natural foods with the recommended dietary allowances for all known nutrients. After a 30-d stabilization period, subjects were randomly assigned to either an intervention group (n = 10) supplemented daily with capsules containing 3.9 g of CLA or a control group (n = 7) that received an equivalent amount of sunflower oil. The CLA capsules (CLA 65%) contained four major cis/trans geometric isomers (11.4% 9 cis-,11 trans-18:2; 10.8% 8 trans-,10 cis-18:2; 15.3% 11 cis-,13 trans-18:2; and 14.7% 10 trans-,12 cis-18:2) and their corresponding cis/cis (6.74% total) and trans/trans (5.99% total) varieties in smaller amounts. Fasting blood was drawn on study days 30 (end of the stabilization period), 60 (midpoint of the intervention p...Continue Reading

References

Jul 1, 1994·Atherosclerosis·K N LeeM W Pariza
Feb 15, 1994·Biochemical and Biophysical Research Communications·C C MillerM E Cook
Mar 10, 1997·Biochimica Et Biophysica Acta·J L SébédioW W Christie
Feb 12, 1998·The American Journal of Clinical Nutrition·B K HerbelT D Shultz

❮ Previous
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Citations

Jan 16, 2007·Journal of Physiology and Biochemistry·V NavarroM P Portillo
Aug 19, 2007·Lipids·Sarah K GebauerPenny M Kris-Etherton
Oct 19, 2006·Current Atherosclerosis Reports·Margo A Denke
May 28, 2005·Biochimica Et Biophysica Acta·Patricia L MitchellRoger S McLeod
Oct 18, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S O'Hagan, A Menzel
Jul 23, 2009·The British Journal of Nutrition·Robert Ringseis, Klaus Eder
Feb 3, 2012·Nutrition Research Reviews·Tracy A McCrorieM Barbara E Livingstone
Mar 28, 2013·European Journal of Clinical Nutrition·I A BrouwerM B Katan
Feb 23, 2011·The Journal of Biological Chemistry·Johannes SchmidtEvi Kostenis
Mar 31, 2006·The British Journal of Nutrition·Anu M TurpeinenJ Thomas Brenna
Jun 18, 2005·The Proceedings of the Nutrition Society·Sabine TriconParveen Yaqoob
Mar 29, 2012·Critical Reviews in Food Science and Nutrition·Allison Dilzer, Yeonhwa Park
Feb 15, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Philip C Calder
Feb 16, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Sabine Tricon, Parveen Yaqoob
Dec 6, 2008·Epidemiology·Susanna C LarssonJarmo Virtamo
May 19, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·A Brianne ThrushDavid J Dyck
Sep 27, 2007·Lipids in Health and Disease·Anna HaugOdd M Harstad
Aug 1, 2012·Polish Journal of Veterinary Sciences·J OleszczukE Skopińska-Skopińska
Jun 1, 2012·The American Journal of Clinical Nutrition·Nelsy Castro-WebbHannia Campos
May 7, 2014·Journal of Strength and Conditioning Research·Nathaniel D M JenkinsJoel T Cramer
Aug 1, 2008·Nutrition Reviews·Mélanie PlourdePeter Jh Jones
May 16, 2009·The Journal of Nutritional Biochemistry·Yunkyoung Lee, John P Vanden Heuvel
May 26, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·A ZabalaA Fernández-Quintela
May 3, 2006·The Journal of Nutritional Biochemistry·Arunabh BhattacharyaGabriel Fernandes

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