The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat

Journal of Radiation Research
Daryoush Shahbazi-GahroueiNaser Naghdi

Abstract

The aim of this study was to investigate the effect of continuous extremely low frequency magnetic fields (ELF-MFs) with a frequency of 10 Hz and an intensity of 690-720 μT on the level of 5-hydroxyindolacetic acid (5-HIAA) in adult male Wistar rats. A total of 24 adult Wistar male rats were used, and after exposure with an ELF-MF for 15 successive days, all rats in each test were anesthetized with chloral hydrate. Then, they were placed in a stereotaxic frame for surgery and a microdialysis process. Dialysate samples were analyzed to measure the amount of 5-HIAA by high performance liquid chromatography (HPLC) using electrochemical detection. Results showed that ELF-MF exposure for 15 days, 1 h daily, was not effective in altering the level of 5-HIAA. However, ELF-MF exposure for 15 days, 3 h daily, decreased the level of the 5-HIAA in the raphe nucleus. It can be concluded that ELF-MFs affect the serotonergic system and may be used to treat nervous system diseases. This study is an initial step towards helping cure depression using ELF-MFs.

References

Dec 1, 1992·Electroencephalography and Clinical Neurophysiology·G B BellA L Chesson
May 31, 1990·Biochemical and Biophysical Research Communications·A LerchlR J Reiter
Mar 12, 1985·European Journal of Pharmacology·W A WolfD M Kuhn
Jan 1, 1981·Bioelectromagnetics·B W WilsonR D Phillips
May 1, 1994·Journal of the Neurological Sciences·G B BellA L Chesson
Aug 6, 2000·Pathophysiology : the Official Journal of the International Society for Pathophysiology·H KabutoN Ogawa
Apr 7, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andrew A MarinoClifton Frilot
Apr 3, 2009·Current Protocols in Neuroscience·Agustin ZapataToni S Shippenberg
Dec 2, 2011·General Physiology and Biophysics·Li Y ChuJi H Jeong
Jun 21, 2013·Electromagnetic Biology and Medicine·Daryoush Shahbazi-GahroueiMilad Baradaran-Ghahfarokhi
Dec 18, 2013·General Physiology and Biophysics·Pavan K ManikondaChivukula Subramanyam
Nov 2, 2014·Journal of Radiation Research·Yanchun ZhangChenggang Zhang

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