PMID: 8950004Nov 1, 1996Paper

The effect of continuous intraventricular infusion of L1 and NCAM antibodies on spatial learning in rats

Behavioural Brain Research
S AramiH Welzl

Abstract

Recent studies suggest a role of the neural cell adhesion molecules L1 and NCAM in mechanisms of memory storage. In the present study we analyzed the effect of continuous intraventricular infusion of polyclonal antibodies directed against L1 (antiL1) or NCAM (antiNCAM) on the performance of male Wistar rats during the acquisition and retention of a spatial learning task (Morris water-maze). In this task animals have to learn the spatial position of a hidden escape platform in a water tank to escape onto it. During acquisition of the task animals with continuous infusion of antiNCAM - but not those infused with antiL1 - showed day-dependent attenuated learning in comparison to controls (P = 0.001). Control animals were either injected with vehicle (PBS) or with polyclonal antibodies raised against liver cell membrane. When the escape platform was removed during the retention test (transfer test), the performance of animals continuously infused with antiL1 as well as those continuously infused with antiNCAM showed an impaired search pattern when compared with the performance of control animals (P = 0.001 and 0.04, respectively). Whereas control animals spent up to 46% of their time searching for the platform in the correct quadra...Continue Reading

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Citations

Jan 21, 2000·Hippocampus·V Ramírez-AmayaF Bermúdez-Rattoni
May 20, 1998·Molecular Neurobiology·K C BreenF D Hayes
Jul 23, 2013·Neurobiology of Learning and Memory·Inmaculada Pereda-PérezCésar Venero
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Oct 23, 1997·Current Opinion in Cell Biology·M Schachner
Apr 5, 2003·Molecular and Cellular Neurosciences·Ling DongMelitta Schachner
Nov 20, 2004·Nature Reviews. Neuroscience·Carmen Sandi
Apr 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael TsooryGal Richter-Levin
Jun 26, 2012·Psychiatry and Clinical Neurosciences·Guillaume FondDelphine Capdevielle
Jan 28, 2005·The European Journal of Neuroscience·Shira KnafoCésar Venero
Mar 20, 2008·Neuro-Signals·Guo ShaoGuo-Wei Lu
Mar 16, 2013·Neurochemical Research·Glenn DalléracValérie Doyère
Dec 2, 2008·Neurobiology of Learning and Memory·Reto BisazCarmen Sandi
Mar 24, 2006·The European Journal of Neuroscience·César VeneroCarmen Sandi

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