The effect of continuous irradiation on cell proliferation and maturation in small intestinal epithelium.

Cell and Tissue Kinetics
R P RijkeH Galjaard

Abstract

Autoradiographic studies and scintillation counting of crypt material after pulse labelling with 3H-thymidine showed that during continuous irradiation with 290 rads/day a reduced proliferative activity is present in the crypts of rat small intestine after 1 day of irradiation and of normal activity during the remaining period (5 days) irradiation. After cessation of irradiation an increase in proliferative activity can be observed after 1 day of recovery. From the time (36-48 hr after starting of the irradiation) that the number of villus cells is reduced an expansion of the proliferation zone in the crypt was observed. Both effects last until 1 day of recovery after cessation of irradiation. The process of crypt cell maturation and of villus cell function has also been studied during and after continuous irradiation by micro-chemical enzyme analyses in isolated crypts and villi. It was found that the expansion of the proliferation zone in the crypt is accompanied by a decrease in activity of only those enzymes (i.e. non-specific esterases) which normally become active during crypt cell maturation. The activity of enzymes normally present mainly in the functional villus cells remained relatively unaffected by changes in crypt ...Continue Reading

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Citations

Jan 1, 1982·Archives of Dermatological Research·S Gutschmidt, D Tsambaos
Jan 1, 1972·Biulleten' eksperimental'noĭ biologii i meditsiny·L E Sil'vestrova
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Jul 1, 1977·Cell and Tissue Kinetics·R P RijkeH M Plaisier
Dec 1, 1997·Medizinische Klinik·K F RabeH Magnussen

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