The effect of continuous or pulsatile administration of oxytocin to ewes at 126 to 136 days' gestation on myometrial activity and fetal oxygenation

American Journal of Obstetrics and Gynecology
G PimentelP W Nathanielsz

Abstract

Oxytocin was infused either continuously or in pulses to pregnant ewes to compare the responses of myometrial activity (contractures) and changes in fetal arterial PO2. Group 1 (n = 5) was infused with saline solution throughout the experiment. In group 2 (n = 5) oxytocin was infused continuously (160 microU.kg-1.min-1) for 7 days whereas group 3 (n = 5) ewes received 960 microU.kg-1.min-1 for 5 minutes every 30 minutes for 7 days. Contracture frequency increased in both oxytocin-infused groups. With continuous infusion contracture frequency returned to preinfusion levels during the last 4 days of infusion, whereas the pulsatile infusion contracture frequency remained increased throughout the infusion period. Fetal arterial PO2 was decreased throughout the 7 days of infusion in both oxytocin-infused groups. Pulsatile group fetal arterial PO2 levels remained decreased after the oxytocin infusion was stopped. These findings show: (1) Myometrial response to oxytocin in late pregnant ewes is influenced by the mode of administration; (2) administration of oxytocin to pregnant ewes resulted in a decrease in fetal PO2, and thus fetal hypoxemia cannot be attributed exclusively to increased contracture frequency.

References

Feb 15, 1985·American Journal of Obstetrics and Gynecology·J P FigueroaP W Nathanielsz
Sep 1, 1984·Journal of Reproduction and Fertility·R Garcia-VillarY Ruckebusch
Feb 15, 1984·American Journal of Obstetrics and Gynecology·C A JansenP W Nathanielsz

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Citations

Aug 18, 2016·Frontiers in Pediatrics·Katrina Suzanne Evers, Sven Wellmann

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