PMID: 61040Sep 1, 1975Paper

The effect of Corynebacterium parvum therapy on immunoglobulin class and IgG subclass levels in cancer patients

British Journal of Cancer
K JamesD Catty

Abstract

Detailed serological studies have been undertaken in a small group of cancer patients receiving nonspecific immunotherapy with Corynebacterium parvum (C. parvum). These patients included 4 cases of recurrent malignant melanoma, 2 of stomach cancer and 2 of recurrent breast cancer. They all received an initial i.v. infusion of 20 mg of a formol killed suspension of C. parvum followed by 2 mg (i.m.) at weekly intervals for 10-11 weeks. This protocol consistently resulted in an increase in the circulating IgG levels of all patients but had a variable effect on their IgA, IgM and IgE levels. Increases in the concentration of all 4 IgG subclasses contributed to the overall increase in IgG levels and these changes ranked IgG2 greater than IgG1 greater than IgG3 = IgG4. It also had an inconsistent effect upon the levels of alpha-macroglobulin in pregnancy but the levels of normal serum alpha2-macroglobulin were virtually unchanged. Pre-existing antibodies to C. parvum were noted in all the patients. Titres rose appreciably following C. parvum administration and remained at high, though fluctuating levels, throughout the 100-day period of observation. Absorption studies suggested that the development of antibodies to C. parvum accounte...Continue Reading

Citations

May 1, 1979·Diseases of the Colon and Rectum·I R GoughW Burnett
Jun 1, 1979·Journal of Cutaneous Pathology·L Nathanson
Oct 7, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Zhen QuMing-hui Zhao
Mar 1, 1977·Infection and Immunity·G WolbergJ K Whisnant

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