Abstract
Crocin as a carotenoid exerts anti-oxidant, anti-inflammatory, anti-cancer, neuroprotective and cardioprotective effects. Besides, the increasing prevalence of diabetes mellitus and its allied complications, and also patients' desire to use natural products for treating their diseases, led to the design of this study to evaluate the efficacy of crocin on glycemic control, insulin resistance and active adenosine monophosphate-activated protein kinase (AMPK) levels in patients with type-2 diabetes (T2D). In this clinical trial with a parallel-group design, 50 patients with T2D received either 15-mg crocin or placebo, twice daily, for 12 weeks. Anthropometric measurements, dietary intake, physical activity, blood pressure, glucose homeostasis parameters, active form of AMPK were assessed at the beginning and at the end of the study. Compared with the placebo group, crocin improved fasting glucose level (P = 0.015), hemoglobin A1c (P = 0.045), plasma insulin level (P = 0.046), insulin resistance (P = 0.001), and insulin sensitivity (P = 0.001). Based on the within group analysis, crocin led to significant improvement in plasma levels of glucose, insulin, hemoglobin A1c, systolic blood pressure, insulin resistance and insulin sensit...Continue Reading
References
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
Sep 19, 2000·Medicine and Science in Sports and Exercise·B E AinsworthA S Leon
Mar 22, 2003·Journal of Ethnopharmacology·M FatehiZahra Fatehi-Hassanabad
Jan 17, 2004·Lancet·UNKNOWN WHO Expert Consultation
Sep 15, 2005·Annals of Epidemiology·Anne G WheatonMichele Reyes
Oct 29, 2005·Planta medica·Liang XiYabing Zhang
May 23, 2006·The Journal of Nutritional Biochemistry·Liang XiYabing Zhang
May 7, 2009·Cell Metabolism·Bei B ZhangCai Li
Dec 17, 2009·Phytotherapy Research : PTR·Mohsen ImenshahidiYaser Javadpour
Sep 6, 2012·Phytotherapy Research : PTR·Saeed ShiraliManouchehr Nakhjavani
Sep 18, 2012·Food Chemistry·Changkeun KangEuikyung Kim
Feb 27, 2013·Journal of Medicinal Food·Ziba RajaeiSomayeh Shafiee
Jun 24, 2014·Pharmacopsychiatry·F FadaiS Zahra Bathaie
Jan 14, 2016·Blood Pressure·Paria AzimiHossein Khosravi-Boroujeni
Jan 26, 2016·Chemico-biological Interactions·Nehal M ElsherbinyMohammed M H Al-Gayyar
Apr 7, 2016·Current Medicinal Chemistry·Hitender Sharma, Sunil Kumar
Apr 28, 2016·Life Sciences·Serdar OrucSefa Celik
Apr 29, 2016·Scientific Reports·Firouzeh DehghanMohammad Ali Azarbayjani
Oct 6, 2016·Arquivos de neuro-psiquiatria·Z RajaeiH Alaei
Jul 25, 2017·International Immunopharmacology·Haidy YosriNariman M Gameil
Dec 24, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Habib YaribeygiAmirhossein Sahebkar
Feb 8, 2018·Chemico-biological Interactions·Hadeer O Abou-HanyHatem A Salem
Feb 9, 2018·Journal of Research in Pharmacy Practice·Tayyebe KermaniOmid Rajabi
Feb 27, 2018·European Journal of Nutrition·Vladimir VuksanMichael Z C Li
Mar 14, 2018·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Alireza MilajerdiShahin Akhondzadeh
Mar 20, 2018·American Journal of Ophthalmology·Samaneh SepahiSayyed Abolghasem Sajadi Tabassi
Apr 2, 2018·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Roghayeh ZareMojtaba Heydari
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rania El-FawalMona F Mahmoud
Dec 6, 2018·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Dec 19, 2018·Diabetes Care·UNKNOWN American Diabetes Association
Jan 7, 2019·Lipids in Health and Disease·Ke-Wei WangJian-Huan Chen
Jan 22, 2019·Clinical Nutrition ESPEN·Golbon SohrabFereidoun Siasi
Jan 25, 2019·Bioscience Trends·Ming GuKai Fang
Apr 4, 2019·Phytotherapy Research : PTR·Armaghan Moravej AlealiBahman Cheraghian
Aug 9, 2019·Environmental Toxicology and Pharmacology·Mahmoud M SamahaHatem A Salem
Dec 18, 2019·European Journal of Nutrition·Zahra YariAzita Hekmatdoost
Feb 6, 2020·Archives of Physiology and Biochemistry·Babak RoshanravanTahereh Farkhondeh
Apr 30, 2020·Saudi Journal of Biological Sciences·Mardi M Algandaby