PMID: 812895Dec 1, 1975

The effect of cromolyn sodium powder as a treatment for ragweed pollinosis

The Journal of Allergy and Clinical Immunology
K M LeifermanG J Gleich

Abstract

The effect of treating ragweed pollinosis with intranasal cromolyn sodium powder was evaluated in 26 patients in a double-blind clinical study. Thirteen matched patient pairs were treated by either nasal insufflation of cromolyn sodium powder, 20 mg three times daily, or by a placebo powder. Patients were monitored for severity of symptoms by means of daily symptom diaries collected weekly throughout the pollen season. Serum samples were obtained in July prior to the ragweed season and following the ragweed season during the first and fourth weeks of October for the determination of ragweed-specific IgE antibody levels by the radioallergosorbent test. A significant reduction in symptom severity was observed in the treated patients with high preseasonal levels of IgE antibody to ragweed. Initially the levels of IgE antibody to ragweed did not differ between the two groups. IgE antibody levels increased in both groups after pollen exposure, but the treated group showed a significantly greater rise in IgE antibody levels. The results suggest that treatment with cromolyn sodium enhanced IgE antibody response to pollen exposure and significantly reduced the severity of hay fever symptoms in patients with high preseasonal levels of I...Continue Reading

References

Apr 1, 1981·The Journal of Allergy and Clinical Immunology·R L JacobsR N Boswell
Aug 1, 1979·Current Problems in Pediatrics·S C SiegelR M Katz
Sep 1, 1977·The Journal of Allergy and Clinical Immunology·G J GleichL L Henderson
Sep 1, 1979·The Journal of Allergy and Clinical Immunology·P W WelshG J Gleich
Jan 27, 2007·The Cochrane Database of Systematic Reviews·M A CalderonS Durham
Jan 1, 1984·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·F H Leffert

Citations

Jan 1, 1975·The Journal of Allergy and Clinical Immunology·L L HendersonG J Gleich
May 1, 1975·The Journal of Allergy and Clinical Immunology·G J Gleich, R T Jones
Aug 1, 1973·The Journal of Allergy and Clinical Immunology·M N BlumenthalR B McHugh
Jul 1, 1972·The Journal of Laryngology and Otology·I Hopper, J P Dawson
Aug 1, 1972·The American Review of Respiratory Disease·F A IraniM T Newhouse
Oct 1, 1972·The Journal of Allergy and Clinical Immunology·I L BernsteinM Yamate
Sep 1, 1972·Acta Allergologica·M G Thorne, W H Bradbeer
Dec 1, 1972·Acta Allergologica·N MygindM B Jorgensen
Sep 1, 1971·The American Review of Respiratory Disease·J H ToogoodD R McCourtie
Jun 1, 1971·Clinical Allergy·G Taylor, P R Shivalkar

Related Concepts

Vicrom
Radioallergosorbent Test
Immunoglobulin E
Pollen
Hay Fever
Cromolyn Sodium
Ambrosia
Clinical Trials
Administration, Intranasal
Bee pollen

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