The effect of cryosurgical ablation of the prostate on erectile function

British Journal of Urology
S AboseifP R Carroll

Abstract

To investigate the incidence and identify the possible cause of erectile dysfunction after cryoablation of the prostate. Erectile function was examined prospectively in 15 sexually active men (aged 59-72 years) who underwent cryoablation of the prostate for clinically localized prostate cancer. Erectile function was assessed before and 6 months after treatment; after intracavernosal injection with 10 micrograms of prostaglandin E1 (PGE1), the degree and duration of erection, the size of the cavernosal arteries, the penile arterial blood flow velocity, and the time to achieve peak flow were evaluated using high-resolution ultrasonography and colour pulsed-Doppler spectral analysis. Post-operatively, all patients initially reported an inability to achieve an erection sufficient for vaginal intercourse. At 6 months' follow-up, erectile dysfunction persisted in nine, with minimal or no response to the intracavernosal PGE1 injections, there was a significant decrease in the peak velocity of blood flow within cavernosal arteries and a significant increase in the time to achieve peak arterial flow. Although many factors may contribute to erectile dysfunction after cryoablation of the prostate, vascular injury plays a major role.

Citations

Jan 21, 2006·The Journal of Sexual Medicine·Iñigo Sáenz de TejadaUlf Simonsen
Nov 18, 2005·The Urologic Clinics of North America·Robert C Dean, Tom F Lue
Dec 19, 2003·The Urologic Clinics of North America·Katsuto Shinohara
May 25, 2005·Journal of Endourology·Nicolette K JanzenArie S Belldegrun
Sep 27, 2006·Journal of Endourology·Duke K BahnJohn C Rewcastle
Dec 12, 2007·International Journal of Clinical Oncology·Katsuto Shinohara

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