The effect of d-amphetamine and ephedrine on smoking attitude and behavior

Addictive Behaviors
R B LowR J Cadoret

Abstract

Using a double blind, randomized, latin square design, 17 light smokers and 6 heavy smokers were given three times per day doses of placebo, 5 mg amphetamine sulfate, 7.5 mg amphetamine sulfate, 25 mg ephedrine hydrochloride or 50 mg ephedrine hydrochloride. Compared to placebo, active drug produced a statistically significant drop in feeling of addiction to cigarettes (p = 0.022). Ephedrine was reported to be more effective than amphetamine (p = 0.046). Subjects reported similar changes in feeling of enjoyment of smoking. Active drug produced a statistically significant drop in the actual amount of tobacco smoked in heavy smokers (p = 0.028), but not in light smokers. Only two smokers were able to quit completely during the experiment, and one of those people resumed smoking after she stopped taking medication. Possible explanations of these findings are discussed.

References

Jul 19, 1978·Psychopharmacology·M E JarvikE R Gritz
Jul 6, 1978·The New England Journal of Medicine·W S Aronow
Jun 1, 1977·American Journal of Public Health·T M VogtS B Hulley
May 28, 1976·Psychopharmacologia·L T Kozlowski
Jul 19, 1973·Psychopharmacologia·B BrantmarkH Westling
Jan 1, 1973·Psychopharmacologia·I P StolermanM E Jarvik
Jan 1, 1973·The International Journal of the Addictions·P W Bradshaw
Mar 1, 1971·The British Journal of Medical Psychology·M A Russell
Jun 1, 1967·Archives of Environmental Health·P M DensenE W Jones
Aug 1, 1983·Pharmacology, Biochemistry, and Behavior·O F PomerleauS O Shanahan
Mar 27, 1980·The New England Journal of Medicine·J R White, H F Froeb

❮ Previous
Next ❯

Citations

Sep 17, 2002·Current Psychiatry Reports·Maria A Sullivan, Lirio S Covey
Jul 1, 1995·Addictive Behaviors·M D RobinsonH J Norton
Apr 17, 1998·Drug and Alcohol Dependence·M S ReidS P Berger
Apr 8, 1998·The Journal of Psychology·J B Murray
Jan 5, 2002·Pharmacotherapy·M KotlyarB D Jamerson
Apr 1, 1987·British Journal of Addiction·R West, N Schneider
Jan 1, 1995·International Journal of Psychiatry in Medicine·V F Holmes
Dec 1, 1996·Clinical Pharmacology and Therapeutics·J NørregaardH B Jakobsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.