The effect of daily challenge with Trichostrongylus colubriformis larvae on the nutrition and performance of immunologically-resistant sheep

Veterinary Parasitology
A E KimamboP J Dewey

Abstract

Immunological resistance to Trichostrongylus colubriformis was developed in sheep by challenging them with 2500 larvae per day for 34 weeks. They were then rested for 24 weeks before being re-challenged with the same dose rate of the same larvae for 10 weeks. Nutritional, haematological and parasitological parameters were measured during the first 8 weeks of re-challenge infection. There were no faecal worm eggs excreted during the re-challenge infection. There was a small but significant increase in plasma-N leakage from Days 4 to 9 of dosing but this then declined to initial levels. There was no other detectable nutritional disturbance associated with re-infection. Re-challenge caused a rapid development of eosinophilia which peaked during Week 6 before declining to levels of the control animals by Week 8. Sheep resistant to T. colubriformis appear to be able to re-activate their immunological mechanisms when re-challenged with the parasite with little associated nutritional penalty.

Citations

Dec 1, 1993·International Journal for Parasitology·E H Barnes, R J Dobson
Nov 1, 1996·International Journal for Parasitology·M F van Houtert, A R Sykes
Jul 15, 1997·Veterinary Parasitology·D A IsrafR L Coop
Feb 1, 1993·The Proceedings of the Nutrition Society·J C MacRae
Jun 19, 2002·The Proceedings of the Nutrition Society·J G HoudijkI Kyriazakis
Sep 27, 2014·Journal of Immunology Research·Sarah Jane Margaret PrestonDavid Piedrafita
May 23, 2017·International Journal for Parasitology·J G M HoudijkM R Hutchings

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