The effect of decongestive nosedrops on human respiratory mucosa in vitro

The Laryngoscope
O H BergS K Steinsvåg

Abstract

The aim of this study was to investigate the morphological effects of decongestive drops and sprays on human respiratory mucosa in vitro. Precultured fragments of adenoid tissue in a specially designed tissue culture system were exposed to decongestive preparations for 10 minutes once a day for 10 days. Tissue exposed to preparations preserved with benzalkonium chloride and tissue exposed to benzalkonium chloride alone underwent severe morphological alterations. Unpreserved decongestive substances did not have this effect. Benzalkonium chloride is a well-documented toxic substance in several respects. Supported by previous studies, it may seem unfortunate to use it as an additive in decongestive preparations.

Citations

Jul 9, 2004·Mutation Research·Norbert H KleinsasserAlbert W Rettenmeier
Dec 23, 2008·Biochemical and Biophysical Research Communications·Seong Kook ParkYoung-Il Yang
Jul 7, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Neil F Johnson
Oct 17, 2012·The Laryngoscope·Merrill A BielNicolas Loebel
Apr 21, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Larisa TratnjekMateja Erdani Kreft
Jun 6, 2000·Advanced Drug Delivery Reviews·F W MerkusE Marttin

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