PMID: 9526966Apr 4, 1998Paper

The effect of dehydroepiandrosterone combined with a low-fat diet in spontaneously obese dogs: a clinical trial

Obesity Research
I D KurzmanE G MacEwen

Abstract

Dehydroepiandrosterone (DHEA) has been shown to have antiobesity activity in rodents and spontaneously obese dogs. This study evaluated the effect of DHEA or placebo combined with a low-fat/high-fiber diet in spontaneously obese dogs in a clinical trial. Spontaneously obese, euthyroid dogs, referred to the University of Wisconsin School of Veterinary Medicine for treatment of their obesity, were evaluated for percent overweight, rate of weight loss, serum cholesterol, plasma lipoprotein and serum biochemistry profiles, complete blood count, and endocrine profiles (T4, T3, cortisol, insulin, and DHEA-sulfate). DHEA-treated dogs had a significantly increased rate of actual and percent excess weight loss compared with placebo-treated dogs. Serum cholesterol decreased in both treatment groups; however, DHEA-treated dogs had a significantly greater reduction than placebo-treated dogs. DHEA-treated dogs had a significant 32% reduction in total plasma cholesterol, which was due to a 27% reduction in the lipoprotein fraction containing the high-density lipoprotein (HDL) and a 50% reduction in the lipoprotein fraction containing the low-density lipoprotein (LDL). Placebo-treated dogs did not have a significant reduction in total plasma ...Continue Reading

References

May 1, 1977·Lipids·T T YenM M Greenberg
Dec 15, 1978·Experientia·T T YenJ M Acton
Jan 1, 1991·Proceedings of the Society for Experimental Biology and Medicine·M P Cleary
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·J E NestlerW G Blackard
Jan 1, 1990·The International Journal of Biochemistry·M P Cleary
Sep 1, 1990·The Journal of Clinical Endocrinology and Metabolism·J F Mortola, S S Yen
Sep 1, 1990·The Journal of Nutrition·P F MohanM P Cleary
Nov 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S WelleM Statt
Dec 11, 1986·The New England Journal of Medicine·E Barrett-ConnorS S Yen
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J E NestlerW G Blackard
Feb 1, 1987·Endocrine Reviews·A D MooradianS G Korenman
Apr 5, 1986·The Veterinary Record·A T Edney, P M Smith
Dec 1, 1985·Annals of Internal Medicine·T B Van Itallie
Jul 1, 1972·The Journal of Clinical Endocrinology and Metabolism·W D DruckerA L Verde
Feb 1, 1969·The Journal of Clinical Endocrinology and Metabolism·T Yamaji, H Ibayashi
May 23, 1970·The Veterinary Record·E Mason
Jul 1, 1984·The Journal of Nutrition·M P ClearyB Jenks
Sep 1, 1984·The Journal of Clinical Endocrinology and Metabolism·N OrentreichJ H Vogelman
Apr 14, 1983·The New England Journal of Medicine·P WahlB Rifkind
Mar 28, 1995·Biochemical and Biophysical Research Communications·Y KimM Suzuki
Mar 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C D BerdanierM K McIntosh
Sep 1, 1957·The Journal of Clinical Endocrinology and Metabolism·C J MIGEONT H SHEPARD

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Citations

Mar 6, 2003·Lipids·Henry LardyPadma Marwah
Oct 29, 2011·The Journal of Sexual Medicine·Abdulmaged M TraishAndre T Guay
Mar 21, 2003·Metabolism: Clinical and Experimental·P MauriègeY Deshaies
Jun 4, 2008·Journal of the American Veterinary Medical Association·Philip RoudebushSean J Delaney
Jul 28, 2019·Clinical and Experimental Pharmacology & Physiology·Ting-Ting WuXiang Xie
Nov 17, 2020·Frontiers in Veterinary Science·Gianfranco GabaiLieta Marinelli

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