The effect of delayed reperfusion following infarction in the rat on structural changes in viable myocardium

Cardiovascular Research
K McDonaldM Hartman

Abstract

Evidence indicates that patency of the infarct related artery following the completion of myocardial necrosis can attenuate ventricular remodeling. Data have also demonstrated that inhibition of infarct expansion contributes to the anti-remodeling effect of delayed reperfusion. However, the influence of a patent artery on components of the remodeling process in the viable myocardium is poorly understood. Myocyte morphometrics (isolated cell technique) and collagen content (hydroxyproline analysis) were assessed 28 days following experimental myocardial infarction from rats with permanently ligated left coronary vessels (NRP; n = 10) compared with rats who underwent reperfusion 150 minutes after ligation (RP; n = 11) and a sham-operated group (n = 10). Analysis of infarct size (planimetry) in a separate group of rats demonstrated that reperfusion at this late time point did not reduce infarct size (NRP: 33 +/- 3 vs. RP: 35 +/- 5%). Myocyte length in RP rats was less than in NRP rats in viable, non-infarcted left ventricular tissue (155 +/- 3 vs. 167 +/- 4 microns, p = 0.02), in the right ventricle (154 +/- 4 vs. 167 +/- 3 microns, p = 0.02) and in the septum (158 +/- 4 vs. 169 +/- 4 microns, p = 0.05). Reperfusion also attenuate...Continue Reading

Citations

Mar 6, 1998·The Journal of Laboratory and Clinical Medicine·K M McDonald
Nov 20, 2015·Journal of Molecular and Cellular Cardiology·Roberta A Gottlieb, Somayeh Pourpirali
Jun 28, 2000·Progress in Cardiovascular Diseases·O C Marroquin, G A Lamas
Dec 7, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Roberta A Gottlieb, Aleksandr Stotland
Aug 18, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K Ytrehus

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