The effect of dendritic cells activated by OK-432 and pulsed with antigens on cytokine induced killers

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yong-Qian Shu, Yanhong Gu

Abstract

To study the effect of OK-432 on the maturation and function of human peripheral blood monocyte-derived dendritic cells, and the effect of these dendritic cells on the proliferation and anti-tumor function of cytokine induced killers. Through the analysis of DCs' surface molecules, the detection of the proliferation and anti-tumor function of CIKs activated by DCs, we researched the influence of OK-432 on DCs and CIKs. OK-432 have the potential of promoting DCs to express CD1a, CD80, CD83, HLA-DR highly, which is stronger than LPS; DCs activated by OK-432 can facilitate the proliferation and function of CIKs. OK-432 can induce DCs' maturation and can thus promote CIKs' functions.

References

Apr 10, 1996·Cellular Immunology·I G Schmidt-WolfR S Negrin
Mar 1, 1997·Immunology Today·G Girolomoni, P Ricciardi-Castagnoli
Aug 15, 2001·Acta Odontologica Scandinavica·T Kaisho, S Akira

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