The effect of dermatologic precautions on the incidence of rash with addition of lamotrigine in the treatment of bipolar I disorder: a randomized trial

The Journal of Clinical Psychiatry
Terence A KetterKevin P Nanry

Abstract

Prescribing recommendations specify that lamotrigine should ordinarily be discontinued at the first sign of rash, regardless of its type and severity, unless the rash is clearly not drug related. This practice helps to ensure that lamotrigine is discontinued in instances of serious rash (an event occurring in up to 0.13% of cases in bipolar clinical trials) but may lead to unnecessary discontinuation of lamotrigine for cases of nonserious rash arising from nondrug causes. Measures aimed at reducing overall occurrence of dermatologic reactions might reduce the incidence of nonserious rash leading to premature lamotrigine discontinuation. This study assessed the impact of specific instructions designed to decrease risk of dermatologic reactions, including nonserious rash, during initiation of and early treatment with lamotrigine in patients with bipolar I disorder. Outpatients with DSM-IV-diagnosed bipolar I disorder >/= 13 years of age at 188 sites were randomly assigned to receive Usual Care Precautions (UCP; precautions from the patient instructions in the prescribing information for reducing risk of rash including nonserious rash) or Dermatologic Precautions (DP; precautions as above [UCP] plus additional precautions intended...Continue Reading

Citations

Oct 11, 2008·The International Journal of Neuropsychopharmacology·Boris LorbergZubin Bhagwagar
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Andrea CiprianiCorrado Barbui
Dec 19, 2015·International Journal of Psychiatry in Medicine·Nitin Chopra, Jose de Leon
Jul 1, 2009·Expert Review of Clinical Pharmacology·Vivek Datta, Anthony J Cleare
Jul 22, 2014·Journal of Korean Medical Science·Chi-Un Pae

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

Forensic Science International : Synergy
Jeong-Hoon YoonGun-Tae Park
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
E Barrett-ConnorA C Santora
© 2022 Meta ULC. All rights reserved