PMID: 9525832Apr 3, 1998Paper

The effect of dexamethasone on the uptake of cisplatin in 9L glioma and the area of brain around tumor

Journal of Neuro-oncology
C S StraathofJ H Schellens

Abstract

The negative influence of dexamethasone (Dex) on the uptake of cisplatin in brain tumors was investigated in rats bearing 9L glioma. Dex or saline was given intraperitoneally prior to intravenous administration of cisplatin 5 mg/kg. Total Platinum (Pt) concentration was quantified with atomic absorption spectroscopy (AAS) in tumor, brain around tumor (BAT), normal brain and plasma. In the second experiment DNA-adducts of cisplatin were determined in tumor and BAT by AAS. In tumor, there was no difference in the Pt concentration and in the DNA-adduct level between the two treatment groups. In BAT, the Pt level in the Dex group was 0.20 microg/g (SD=0.10 microg/g), which was significantly lower than in the controls (0.53 microg/g (SD=0.21 microg/g); p < 0.001). In addition, the DNA-adduct level in BAT was 23% lower in the Dex treated rats (p=0.05). In normal brain the Pt concentration was 10-fold lower than in tumor tissue. Thus, Dex did not significantly limit the uptake of cisplatin in brain tumor nor did it influence the uptake in normal brain parenchyma. In contrast, in BAT that has a partially disrupted BBB, the concentrations of Pt and DNA-adduct formation were significantly decreased following pretreatment with Dex. The in...Continue Reading

Citations

Jul 30, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·P C NathanB M Feldman
Oct 13, 2006·Current Treatment Options in Oncology·Kevin H Peacock, Glenn J Lesser
Sep 11, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Roger Murayi, Prashant Chittiboina
Jun 17, 2016·Expert Review of Neurotherapeutics·Antonin DréanAhmed Idbaih
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy U LinEric P Winer
Aug 28, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·L Lee DupuisMarianne van de Wetering
Dec 21, 2000·Current Oncology Reports·R CiordiaT Batchelor
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leslie L MuldoonEdward A Neuwelt
Dec 1, 2005·Expert Review of Pharmacoeconomics & Outcomes Research·Martin Jb Taphoorn, Andrew Bottomley
Jun 14, 2008·Critical Reviews in Oncology/hematology·Alicia TosoniAlba A Brandes

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