Dec 1, 1975

The effect of dexamethasone on urinary acidification

Proceedings of the Society for Experimental Biology and Medicine
G PerezC A Vaamonde


Although it is well recognized that mineralocorticoids enhance renal acid excretion, the effect of glucocorticoids on renal acidification is unclear. Oral administration of dexamethasone to six healthy volunteers for 1 week at a daily dose of 4.5 mg was associated with mild respiratory alkalosis and a small but statistically significant increase in baseline urine pH. However, neither the ability to lower urine pH nor to excrete titratable acid and ammonium after NH4Cl acid-loading was altered. Administration of a single intravenous dose of dexamethasone sodium phosphate (7.5 mg) was associated with a significant rise in urine pH and potassium excretion and decreased titratable acid, ammonium , and phosphorus excretion in the absence of changes in blood acid-base status, creatinine clearance, or urine flow.

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Mentioned in this Paper

Glucocorticoid inhalants for obstructive airway disease
Creatinine Clearance Measurement
Flow of Urine
Glucocorticoids, Systemic
Phosphate Measurement
Urine pH Measurement
Acidification - ActCode

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