Dec 1, 1975

The effect of dexamethasone on urinary acidification

Proceedings of the Society for Experimental Biology and Medicine
G PerezC A Vaamonde

Abstract

Although it is well recognized that mineralocorticoids enhance renal acid excretion, the effect of glucocorticoids on renal acidification is unclear. Oral administration of dexamethasone to six healthy volunteers for 1 week at a daily dose of 4.5 mg was associated with mild respiratory alkalosis and a small but statistically significant increase in baseline urine pH. However, neither the ability to lower urine pH nor to excrete titratable acid and ammonium after NH4Cl acid-loading was altered. Administration of a single intravenous dose of dexamethasone sodium phosphate (7.5 mg) was associated with a significant rise in urine pH and potassium excretion and decreased titratable acid, ammonium , and phosphorus excretion in the absence of changes in blood acid-base status, creatinine clearance, or urine flow.

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Mentioned in this Paper

Urine
Electrolytes
Glucocorticoid inhalants for obstructive airway disease
Creatinine Clearance Measurement
Flow of Urine
Glucocorticoids, Systemic
Phosphate Measurement
Urine pH Measurement
Acidification - ActCode
Kidney

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