The effect of dexmedetomidine on nutrient organ blood flow

Anesthesia and Analgesia
C J LawrenceS de Lange

Abstract

The alpha 2-adrenergic agonist dexmedetomidine decreases not only heart rate, myocardial contractility, and oxygen demand, but also cardiac output (Q). To investigate whether this reduction in Q could critically impair perfusion of individual organs, we studied the effect of dexmedetomidine on nutrient blood flow to the heart, brain, kidney, spleen, skin, intestine, liver, and arteriovenous anastomoses using the radioactive microsphere technique. Studies were conducted in 14 dogs with an open chest and anesthetized with either chloralose/urethane (CU) or fentanyl/halothane (FH), to create different baseline conditions. Hemodynamic variables, organ blood flow, arterial and mixed venous oxygen, and lactate content were measured before and after administration of 0.1, 1, and 10 micrograms/kg dexmedetomidine intravenously (IV). After 10 micrograms/kg dexmedetomidine Q decreased in both groups by 50%. The decrease in blood flow varied greatly between the organs. While flow through arteriovenous anastomoses and skin decreased by 70% to 90%, renal blood flow decreased by 30%, cerebral blood flow only when baseline blood flow was high (FH dogs), and left ventricular blood flow only in the CU group, where the largest decrease in hemodyn...Continue Reading

References

Feb 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·M LaubieM Drouillat
Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Jun 1, 1988·European Journal of Clinical Investigation·J D Coffman, R A Cohen
Jun 1, 1987·Hypertension·P W de LeeuwW H Birkenhäger
Mar 1, 1989·Proceedings of the Society for Experimental Biology and Medicine·C H BakerE T Sutton
Jul 1, 1981·Basic Research in Cardiology·F W PrinzenR S Reneman
May 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·K InoueJ O Arndt
Feb 1, 1993·Journal of Cardiothoracic and Vascular Anesthesia·W E FlackeM Sagan
Aug 1, 1996·Journal of Cardiothoracic and Vascular Anesthesia·P M RoekaertsS de Lange

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Citations

May 9, 2009·Acta Veterinaria Scandinavica·Görel NymanGöran Hedenstierna
Sep 19, 2012·The Journal of Veterinary Medical Science·Tokiko Kushiro-BankerRobert Armstrong
Apr 29, 2014·Research in Veterinary Science·S Quirós CarmonaR J Gómez-Villamandos
May 7, 2015·Veterinary Anaesthesia and Analgesia·Stephanie KeatingAndrea Edginton
May 29, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Shoichiro SazukaTatsuya Ichinohe
Sep 6, 2011·The Veterinary Clinics of North America. Small Animal Practice·Pierre Amsellem
Jan 10, 2002·Anesthesiology Clinics of North America·W C Wilson, S Aronson
May 10, 2008·Veterinary Anaesthesia and Analgesia·Asadollah Kariman, R Eddie Clutton
Oct 13, 2011·Veterinary Anaesthesia and Analgesia·Bruno H PypendopJan E Ilkiw
Apr 28, 2011·Journal of Veterinary Pharmacology and Therapeutics·A EscobarJ E Ilkiw
Dec 5, 2014·Journal of Veterinary Emergency and Critical Care·Miriely S DinizPaulo do Nascimento
Nov 5, 1998·Journal of Cardiothoracic and Vascular Anesthesia·S Aronson, R Blumenthal
Jan 5, 2002·Critical Care Clinics·M MazeF Cavaliere
Jun 9, 2005·The Journal of Veterinary Medical Science·Nahed SalehFumihito Ohashi
Aug 25, 2016·Journal of Clinical Anesthesia·Hersh PatelTessa Kate Huncke
Sep 7, 2016·Drug Development and Industrial Pharmacy·Aiwei LiPhilip Chi Lip Kwok
Feb 15, 2002·Journal of Autonomic Pharmacology·D W GaoM W Dae
Jul 28, 2017·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Julia StagegaardMads F Bertelsen
Jan 24, 2007·European Journal of Anaesthesiology·M DurmusM O Ersoy
Oct 31, 2012·American Journal of Veterinary Research·Caroline F BaldoAndre C Shih
Apr 26, 2014·American Journal of Veterinary Research·Bruno H Pypendop, Jan E Ilkiw
Aug 23, 2005·American Journal of Veterinary Research·Kurt A GrimmTomas Martin-Jimenez

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