The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial

Nutrients
Valentina CiappolinoPaolo Brambilla

Abstract

Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (z = 3.9, p = 0.003) or BD with placebo (t = 3.7, p = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future stud...Continue Reading

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
May 8, 1999·Archives of General Psychiatry·A L StollL B Marangell
Mar 1, 2002·Journal of Affective Disorders·G Dore, S E Romans
Jul 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Janice K Kiecolt-GlaserRonald Glaser
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Nov 5, 2003·The Journal of Pediatrics·Sheila M Innis
Nov 26, 2003·The American Journal of Psychiatry·Simona Noaghiul, Joseph R Hibbeln
Feb 3, 2004·The American Journal of Psychiatry·Anabel Martínez-AránManel Salamero
Jun 18, 2005·The Journal of Clinical Psychiatry·Yamima OsherR H Belmaker
Jan 3, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Sophia FrangouPaul McCrone
Sep 13, 2006·The Journal of Clinical Psychiatry·Michael F Green
Nov 9, 2007·Bipolar Disorders·M Elizabeth SubletteStanley I Rapoport
Jun 28, 2008·Neuroscience and Biobehavioral Reviews·Vicent Balanzá-MartínezRafael Tabarés-Seisdedos
Apr 7, 2010·The Journal of Clinical Psychiatry·Ivan J TorresLakshmi N Yatham
May 19, 2011·Journal of Psychiatric Practice·Louisa G SylviaThilo Deckersbach
Apr 14, 2012·Statistical Applications in Genetics and Molecular Biology·Jelle J Goeman, Livio Finos
Aug 14, 2012·Journal of Psychiatric Research·Simon J EvansCharles F Burant
Mar 22, 2013·The American Journal of Clinical Nutrition·Welma StonehouseDavid Kennedy
Aug 2, 2013·The Journal of Nutrition·Jonathan Y BernardUNKNOWN EDEN Mother-Child Cohort Study Group
Jun 9, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C JoffreS Laye
Nov 6, 2014·Military Medicine·Matthew F MuldoonStephen B Manuck
Dec 3, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Norman SalemFrederic Calon
May 16, 2015·Journal of Affective Disorders·A Carlo AltamuraFrancesco Zanelli Quarantini
Jan 8, 2016·Nutrients·Lotte LauritzenCarlo Agostoni
Mar 20, 2016·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Catherine Maud

❮ Previous
Next ❯

Citations

Jun 13, 2021·Neuroscience and Biobehavioral Reviews·Gerwyn MorrisBasant K Puri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

Journal of Psychiatric Research
Miki IgarashiJagadeesh S Rao
Biomolecules & Therapeutics
Kazuhiro TanakaWei-Yi Ong
Maternal Health, Neonatology and Perinatology
Stephanie L Smith, Christopher A Rouse
© 2021 Meta ULC. All rights reserved