PMID: 9180672Jun 1, 1997Paper

The effect of DHEAS on influenza vaccination in aging adults

Journal of the American Geriatrics Society
J DegelauH Hallgren

Abstract

To determine whether simultaneous administration of dehydroepiandrosterone sulfate (DHEAS) exhibits adjuvant activity in the immune response of aging humans by supplementing influenza vaccination with the maximum single dose of DHEAS that could be practically injected subcutaneously (approximately 7.5 mg). A randomized, double-blind, placebo-controlled trial of DHEAS injection with 1993-94 and 1994-95 influenza vaccine in older subjects. In addition, initial safety, tolerability, and control testing with 1993-94 influenza vaccine was conducted in young subjects. An urban primary care geriatrics clinic. Seventy-eight older adult volunteers (mean age 78.61 +/- 3.43 years, range 73-90 years) and 20 younger controls (< 40 years, means age 32.76 +/- 5.39 years) were recruited from clinic and community advertising. Subjects were free of disease or medication known to affect immune function. Immune responses to vaccine at 0, 2, and 4 weeks were measured by vaccine antigen-induced lymphoproliferation in peripheral blood mononuclear cells (PBMC) and serum antibody response by hemagglutination inhibition (HI). The maximum DHEAS dose that could be practically administered subcutaneously was 7.5 mg. Baseline DHEAS levels were significantly...Continue Reading

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Citations

Mar 6, 2010·Research in Veterinary Science·Marina Del Vecchio FilipinJosé Clóvis do Prado
Aug 14, 2008·Experimental Parasitology·Marina Del Vecchio FilipinJosé Clóvis do Prado
Jun 15, 2007·Acta Tropica·Carla Domingues SantosJosé Clóvis do Prado
Jul 23, 2004·Aging Cell·Wiebke Arlt, Martin Hewison
Jul 23, 2004·Aging Cell·Stephen K Butcher, Janet M Lord
Feb 25, 2009·Annals of the New York Academy of Sciences·Moisés E BauerClarice Luz
Jun 16, 2005·Acta Tropica·Carla Domingues dos SantosJosé Clóvis do Prado Júnior
Jul 21, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Wiebke Arlt
Jan 12, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Jon HazeldineJanet M Lord
Nov 15, 1997·Journal of the American Geriatrics Society·R A Miller
Feb 28, 2002·Journal of Clinical Pharmacology·Firoozeh S SalekPatricia Dowley Kroboth
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Oct 17, 2003·Drugs & Aging·Sylvie Legrain, Laurence Girard
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Sep 16, 2021·Endocrine Regulations·Sojit TomoMahendra Garg

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