PMID: 3532771Oct 1, 1986

The effect of dialysate calcium levels on blood pressure during hemodialysis

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Richard A ShermanR P Eisinger

Abstract

A controlled double-blind prospective study was undertaken of the effect of dialysate calcium levels on BP during hemodialysis. Twenty patients and 240 dialyses were studied using a protocol in which patients underwent alternate hemodialyses with dialysate calcium of 2.5 and 3.5 mEq/L. Dialysate composition was otherwise the same. Mean BPs during dialysis were significantly lower at 1.5, 2.5, and 3.5 hours of dialysis when the lower dialysate calcium was used (P = .007 to .02). However, the difference in BP between the high and low dialysate calcium treatments was clinically minor, with a maximum mean difference (at 1.5 hours) of 4.6 mm Hg. Subgroups of patients with frequent hypotension and low or normal serum calcium did not appear more sensitive to the hypotensive effect of low calcium dialysate. Dialysate calcium levels of 2.5 and 3.5 mEq/L thus differ in their effect on intradialytic BP in a statistically significant, but clinically minor, way. Low calcium dialysate thus may prove useful in the management of patients in whom large amounts of enteric calcium absorption are indicated or unavoidable.

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Citations

Jun 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M Sprague, S M Moe
May 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K SchaeferD von Herrath
Sep 1, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nikolaos KaramperisJens Dam Jensen
Feb 7, 2008·Seminars in Dialysis·Christopher W McIntyre
Dec 10, 1991·Clinical Materials·R Vanholder
Jan 10, 2014·Seminars in Dialysis·Piergiorgio Messa, Richard A Sherman
May 11, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Amit LangoteDeborah Zimmerman
Oct 27, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jula K Inrig
Feb 1, 1991·Kidney International·J T Daugirdas
Sep 4, 2009·Kidney International·Jula K InrigLynda A Szczech
Apr 20, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rajiv Agarwal, Robert P Light
Oct 10, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Luca GabuttiMichel Burnier
Aug 10, 2005·Blood Purification·Luca GabuttiClaudio Marone
Oct 4, 2006·Hemodialysis International·Nigel ToussaintPeter G Kerr
Jan 5, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Robert F Reilly
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Related Concepts

Diastolic Blood Pressure
Calcium
Clinical Trials
Double-Blind Method
Hemodialysis
Hypotension
Kidney Failure, Chronic

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