PMID: 6539474Apr 1, 1984Paper

The effect of diazepam on a conditioned emotional response in the rat

Pharmacology, Biochemistry, and Behavior
C Méthot, R Deutsch

Abstract

Benzodiazepines have been shown to stimulate appetite and to affect behaviour in experimental situations that are viewed as providing a model of anxiety. However, the "anti-anxiety" effect is normally demonstrated in situations that use food to motivate behaviour. In the present research, the effect of diazepam was tested on the suppression of drinking brought about by a tone that had been previously paired with shock. Diazepam produced a marked decrease in the amount of time it took the animal to resume drinking, thus providing support for the anti-anxiety effect. Both acute and chronic modes of administration were effective, but the effect was even more clear-cut with chronic administration.

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