The effect of diclofenac acid (Voltaren) on bleomycin-induced pulmonary fibrosis in hamsters.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
D B Chandler, K Young

Abstract

Bleomycin is an anti-neoplastic compound which produces a time- and dose-dependent pulmonary fibrosis. The mechanisms which cause this fibrosis are not known. However, the ability of bleomycin to modulate prostaglandin synthesis, degradation and circulating levels appears to be central to the fibrosis. Previous studies, which have attempt to modulate bleomycin-induced fibrosis by prevention of prostaglandin synthesis have conflicting results. Therefore, the present study was designed to determine the effects of diclofenac acid, a nonsteroidal anti-inflammatory compound, on the development of bleomycin-induced pulmonary fibrosis. Diclofenac acid pretreatment and daily injections prevented lung collagen accumulation after intratracheal bleomycin. In addition diclofenac acid treatment resulted in significantly lower lung collagen level after intratracheal bleomycin at 14 and 21 days when compared with bleomycin alone. These data indicate that diclofenac acid treatment inhibits bleomycin-induced lung fibrosis possible through the prevention of prostaglandins synthesis.

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Citations

Jun 1, 1996·Journal of Pharmacological and Toxicological Methods·F L ClottensB Nemery
Jul 27, 2005·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Seyda Ors KayaMustafa Saçar
Sep 4, 2014·The Journal of Pharmacology and Experimental Therapeutics·Arianna Carolina RosaEmanuela Masini

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