The effect of diet and alcohol on the development of folate deficiency in the rat

British Journal of Haematology
R McGuffinR S Hillman

Abstract

Studies of the rate of depletion of serum and tissue methylated and non-methylated folates were carried our in rats maintained for long periods on either a folate deficient (sucrose-water/sulphathiazole) diet or a deficient diet plus high alcohol intake. By means of implantation of a feeding gastrostomy tube, it was possible to sustain constant blood ethanol levels of between 50 and 300 mg/dl for 3-4 weeks with relatively normal calorie intake and without death of the animal. Using this animal model, which closely resembles severe alcoholism in man, a very rapid depression in serum 5-methyl tetrahydrofolate was observed similar to that reported in alcoholic man. At the same time, release of folates from liver stores was umimpaired by alcohol ingestion. Liver folate store depletion rates were identical for alcoholic and folate starved animals. The explanation for the sudden alcohol suppression of serum folate levels must, therefore, be sought at a point in the internal metabolic sequences of folate other than the delivery of folate stores to plasma.

References

Aug 1, 1973·The American Journal of the Medical Sciences·C J PaineV Dickson
Oct 1, 1972·Analytical Biochemistry·T TamuraE L Stokstad
Mar 1, 1973·The Journal of Clinical Investigation·E R Eichner, R S Hillman
Feb 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·S W ThenenE L Stokstad
Jan 1, 1972·The American Journal of the Medical Sciences·E R EichnerR S Hillman
Feb 1, 1971·The American Journal of Medicine·E R Eichner, R S Hillman
Apr 29, 1971·The New England Journal of Medicine·E R EichnerR S Hillman
Jan 1, 1969·British Journal of Haematology·I ChanarinV Wincour
Jul 1, 1965·Analytical Biochemistry·O D BirdJ W Vaitkus
Jul 1, 1959·The American Journal of Clinical Nutrition·G M BRIGGS
Jan 1, 1963·The American Journal of Clinical Nutrition·V HERBERT
Jan 1, 1964·Journal of Clinical Pathology·M C BENNETTS ARDEMAN
Apr 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·N GROSSOWICZM RACHMILEWITZ
Nov 1, 1964·The Journal of Clinical Investigation·L W SULLIVAN, V HERBERT

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Citations

Apr 29, 1994·Biochemical Pharmacology·N HidiroglouJ Selhub
Nov 1, 1976·British Journal of Haematology·F LaneR S Hillman
Jul 1, 1979·The Journal of Clinical Investigation·S E SteinbergR S Hillman
Feb 19, 2013·Epigenomics·Marisol ResendizFeng C Zhou
Oct 1, 1980·Clinical Toxicology·S E SteinbergR S Hillman
Feb 1, 1982·British Journal of Haematology·S E SteinbergR S Hillman
May 13, 2004·European Journal of Clinical Nutrition·E M LauferP R Taylor
Feb 1, 1983·Journal of Cellular Physiology·S E SteinbergR S Hillman
Aug 19, 2007·The British Journal of Nutrition·Yajun XuYong Li
Nov 1, 1996·Journal of Advanced Nursing·S KirkK A Luker
May 10, 2020·Prenatal Diagnosis·Nina Kaminen-Ahola
Jan 1, 1981·Clinical and Laboratory Haematology·M Y MorganA V Hoffbrand
Jan 1, 1985·Biochemical Pharmacology·D G WeirJ M Scott
Oct 22, 2008·Taiwanese Journal of Obstetrics & Gynecology·Chih-Ping Chen

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