PMID: 9438224Jan 23, 1998Paper

The effect of diet on the Vervet monkey endocrine pancreas

Journal of Medical Primatology
J LouwS Wolfe-Coote

Abstract

Vervet monkeys (Cercopithecus aethiops) used for pancreatic endocrine cell distribution studies were found to have been maintained on different diets. Although the effect of dietary changes on the exocrine pancreas has been described in several animals, little, apart from the effect of malnutrition, has been reported for the endocrine pancreas. Reported here are pancreatic endocrine cell distributions in monkeys on a standard diet (n = 3) compared with monkeys on an atherogenic diet (n = 3). Quantitation of immunolabelled pancreatic endocrine cell types revealed a significant 80% increase in A (glucagon) cell volume in monkeys on an atherogenic diet concomitant with a significant reduction in B (insulin) cell volume to approximately 60% of normal. This reflects a pattern of events that occurs in non-insulin dependent diabetes. An accompanying reduction in PP (pancreatic polypeptide) cell volumes supports our hypothesis that altering A and PP cell volumes could reflect differential gene expression in those cells in the adult in which glucagon and PP are co-localized.

Citations

Oct 24, 1998·General and Comparative Endocrinology·M LarakiC Remacle
May 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patrick OrlandoChristo J F Muller

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