DOI: 10.1101/483412Dec 7, 2018Paper

The effect of dietary intervention on inflammatory markers in patients with type 2 diabetes. An analysis of the Lifestyle Over and Above Drugs in Diabetes (LOADD) study

BioRxiv : the Preprint Server for Biology
Chris S BookerJim I Mann

Abstract

Ninety-three participants with poorly controlled type 2 diabetes despite optimized drug therapy were randomised to receive intensive dietary advice or usual care for six months. Following dietary intervention a significant reduction in interleukin-18 levels was observed, with a ratio of change (95% CI) of 0.90 (0.82-0.99); p = 0.033. Changes in IL-18 correlated with changes in neopterin, r = 0.299 (p = 0.009). Clinical Trial registration ID #[NCT00124553][1]. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT00124553&atom=%2Fbiorxiv%2Fearly%2F2018%2F12%2F07%2F483412.atom

Related Concepts

Biological Markers
Clinical Trials
Diabetes
Diabetes Mellitus, Non-Insulin-Dependent
Diet
Pharmacotherapy
Randomization
Neopterin
Dietary Modification
Iron Deficiency

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