The effect of dietary sainfoin ( Onobrychis viciifolia) on local cellular responses to Trichostrongylus colubriformis in sheep

Parasitology
L Ríos-de ÁlvarezJ F Huntley

Abstract

The effect of sainfoin (Onobrychis viciifolia) hay consumption on the pathophysiology and local cellular responses of growing lambs during infection with Trichostrongylus colubriformis was investigated. Thirty-two lambs, 16 weeks of age, were allocated to 1 of 4 treatment groups (n=8) that were offered either grass (G) or sainfoin (S) hay while concurrently either infected (+), or not (-) with 12,000 L3 T. colubriformis larvae per week for 6 weeks. Liveweight gains were affected by diet (P=0.002) and reduced by infection (P<0.05). Faecal egg count was reduced in S+compared to G+ from days 35 to 42 (P=0.001); however, total egg output, worm burdens at day 42 and worm fecundity were similar between diets (P>0.05).Feeding sainfoin appeared to enhance immune cell development with tissue eosinophils, mast cells and pan T cells present in greater concentrations in S+ than in G+ animals. However, further studies are required to determine if the enhanced immune cell development is a consequence of a greater nutrient supply or a direct influence of sainfoin metabolites on local inflammatory responses to the gastrointestinal nematode T. colubriformis.

References

Jan 1, 1978·Biochemical Society Transactions·M Mantle, A Allen
Nov 1, 1992·Journal of Comparative Pathology·J F Huntley
Jul 1, 1991·Immunology Letters·J E Kay
Jan 1, 1966·Acta Pathologica Et Microbiologica Scandinavica·L Enerbäck
Aug 24, 2000·Journal of Agricultural and Food Chemistry·J P MaraisD Ferreira
Jul 5, 2001·Journal of Comparative Pathology·L GonzálezD Buxton
May 24, 2003·The Veterinary Record·V PaoliniH Hoste
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alan D PembertonHugh R P Miller
Apr 25, 2006·Trends in Parasitology·Hervé HosteSimone O Hoskin
Mar 5, 2008·The Review of Scientific Instruments·G CiavolaK Stiebing

❮ Previous
Next ❯

Citations

Dec 14, 2011·Veterinary Parasitology·Jos G M HoudijkSpiridoula Athanasiadou
Jul 8, 2010·Veterinary Parasitology·C Martínez-Ortíz-de-MontellanoJ F J Torres-Acosta
Jan 31, 2020·Journal of Animal Science·Andrew R WilliamsAlexandra Blanchard
Feb 22, 2017·Animal : an International Journal of Animal Bioscience·H LegendreT Gidenne
Mar 16, 2021·Frontiers in Immunology·Audrey I S Andersen-CivilAndrew R Williams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.