The effect of different contraceptive treatments on the serum concentration of dehydroepiandrosterone sulfate

K L KloveR A Lobo


Twenty-six healthy, non-hirsute women had antecubital venous blood obtained before and during treatment with various contraceptive steroids for the measurement of dehydroepiandrosterone sulfate (DHEA-S). Six of the women were randomized to receive Ortho Novum 1/35 (O/N), 7 were assigned to Ovcon 35 (OV), and another five received Nordette (N). The 6 women ingesting O/N as well as the 7 receiving OV had significant decreases in serum concentrations of DHEA-S (p less than 0.05). The percentage of decrease in DHEA-S in the O/N group (39 +/- 6%) and in the OV group (30 +/- 5%) was not statistically different. The group receiving N showed no changes from baseline measurements. Serum samples from another 8 women who had received subcutaneous implants of levonorgestrel (1-Ng) were obtained. No significant changes occurred in serum DHEA-S between baseline and six-month samples. The data that 1-Ng alone and the combination of 1-Ng and ethinylestradiol did not change DHEA-S levels suggest that 1-Ng does not affect adrenal androgen secretion. Because N, O/N and OV contain similar quantities of ethinylestradiol, these results indicate that norethindrone, but not 1-Ng, has a major suppressive effect upon adrenal androgen secretion.


Sep 1, 1979·The Journal of Clinical Endocrinology and Metabolism·B R CarrJ C Porter
Nov 15, 1980·American Journal of Obstetrics and Gynecology·R A LoboU Goebelsmann


Feb 1, 1996·Archives of Sexual Behavior·N L McCoy, J R Matyas
Aug 16, 2013·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Yvette ZimmermanBart C J M Fauser
Feb 20, 2018·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Mina AmiriFahimeh Ramezani Tehrani

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